{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:55:57Z","timestamp":1789052157954,"version":"build-2803163510"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n            Objective\u2003Idiopathic polyhydramnios is among the most common etiologies of polyhydramnios. However, conflicting evidence exists regarding the relationship between polyhydramnios and neonatal morbidity. We investigated the association between pregnancies with and without idiopathic polyhydramnios and neonatal morbidity at term.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort study of singleton, term (i.e., \u2265370\/7 weeks) pregnancies from 2014 to 2018. Pregnancies complicated by fetal anomalies, pregestational diabetes, and multifetal gestation were excluded. Pregnancies complicated by idiopathic polyhydramnios were defined by the deepest vertical pocket (DVP) \u22658\u2009cm or amniotic fluid index (AFI) \u226524\u2009cm after 20 weeks' gestation and were compared with women without polyhydramnios at time of delivery. These groups were matched 1:2 by gestational age within 7 days at delivery and maternal race. The primary outcome was a composite neonatal morbidity (neonatal death, respiratory morbidity, hypoxic\u2013ischemic encephalopathy, therapeutic hypothermia, seizures, and umbilical artery pH\u2009&lt;\u20097.10). Outcomes were compared between pregnancies with and without idiopathic polyhydramnios. Unadjusted and adjusted risk ratios were estimated using multivariable logistic regression.<\/jats:p><jats:p>\n            Results\u2003Idiopathic polyhydramnios was diagnosed in 192 pregnancies and were matched to 384 pregnancies without polyhydramnios. After adjustment for obesity, women with pregnancies complicated by idiopathic polyhydramnios had an increased risk of composite neonatal morbidity 21.4 versus 5.5% (adjusted risk ratio [aRR]\u2009=\u20094.0, 95% confidence interval [CI]: 2.3\u20136.7). Term neonatal respiratory morbidity was the primary driver 20.3 versus 4.2%, (aRR\u2009=\u20094.8, 95% CI: 2.7\u20138.7) and included higher use of continuous positive airway pressure 19.8 versus 3.4%, p &lt;0.01 and the need for supplemental oxygen at &gt;12\u2009hours of newborn life 6.8 versus 1.8%, p &lt;0.01.<\/jats:p><jats:p>\n            Conclusion\u2003Idiopathic polyhydramnios is associated with term neonatal respiratory morbidity at delivery and during the subsequent hours of newborn life, compared with pregnancies without idiopathic polyhydramnios. Further studies are needed to minimize neonatal morbidity at term.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1739435","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T23:31:01Z","timestamp":1636932661000},"page":"1827-1833","source":"Crossref","is-referenced-by-count":10,"title":["Idiopathic Polyhydramnios and Neonatal Morbidity at Term"],"prefix":"10.1055","volume":"40","author":[{"given":"Brock","family":"Polnaszek","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison G.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas at Austin Dell Medical School, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Raghuraman","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,14]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2018.07.016","article-title":"SMFM consult series #46: evaluation and management of polyhydramnios","volume":"219","author":"J S Dashe","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.7863\/ultra.33.10.1876","article-title":"Fetal imaging: executive summary of a joint Eunice Kennedy Shriver National Institute of Child Health and Human Development, Society for Maternal-fetal Medicine, American Institute of Ultrasound in Medicine, American College of Obstetricians and Gynecologists, American College of Radiology, Society for Pediatric Radiology, and Society of Radiologists in Ultrasound Fetal Imaging Workshop","volume":"33","author":"D W Hershey","year":"2014","journal-title":"J Ultrasound Med"},{"issue":"03","key":"ref3","first-page":"250","article-title":"Ultrasound evaluation of amniotic fluid volume. 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