{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:07Z","timestamp":1787004907414,"version":"build-2736575974"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Objective\u2003While the majority of venous thromboembolism (VTE) during pregnancy events resolve with anticoagulation, long-term complications may occur including (1) postthrombotic syndrome and (2) chronic pulmonary embolism. The objective of this study was to determine risk of these two complications.<\/jats:p>\n                  <jats:p>Study Design\u2003A retrospective cohort study using the MarketScan databases was performed on deliveries from 2008 to 2014. We identified women aged 15 to 54 years diagnosed with acute VTE during pregnancy, the delivery hospitalization, or \u226460 days postpartum who received at least one prescription postpartum for anticoagulants. Risks of (1) chronic PE and (2) postthrombotic syndrome were evaluated for women at 6, 12, 24, and 60 months after delivery hospitalization through 2017 via the International Classification of Diseases, 9th\/10th Revision, Clinical Modification codes.<\/jats:p>\n                  <jats:p>Results\u2003Of 4,267 of 4,128,900 pregnancies complicated by VTE, the majority had DVT alone (61.8%, n\u2009=\u20092,637), while 25.8% had PE alone (n\u2009=\u20091,103) and 12.4% (n\u2009=\u2009527) had both DVT and PE. Of the entire cohort, 3,328 retained insurance coverage at 6 months, 2,823 at 12 months, 2,161 at 24 months, and 831 at 60 months. Restricted to DVT, risk of postthrombotic syndrome was 0.7% at 6 months (n\u2009=\u200917), 1.1% at 12 months (n\u2009=\u200922), 1.7% at 24 months (n\u2009=\u200926), and 2.7% at 60 months (n\u2009=\u200916). Among women with PE diagnoses, the risk of chronic PE was 2.4% at 6 months (n\u2009=\u200930), 3.3% at 12 months (n\u2009=\u200936), 4.2% at 24 months (n\u2009=\u200936), and 7.2% at 60 months (n\u2009=\u200924).<\/jats:p>\n                  <jats:p>Conclusion\u2003In comparison to the general population, the risk of postthrombotic syndrome was lower. In comparison, the risk of chronic PE was similar to the estimates in the general population at comparable time points after PE events. For women with obstetric PE, it may be appropriate to be vigilant for findings and symptoms associated with chronic PE.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0041-1739471","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T18:57:23Z","timestamp":1637607443000},"page":"022-024","source":"Crossref","is-referenced-by-count":2,"title":["Postthrombotic Syndrome and Chronic Pulmonary Embolism after Obstetric Venous Thromboembolism"],"prefix":"10.1055","volume":"40","author":[{"given":"Fergal","family":"O'Shaugnessy","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Rotunda Hospital, Dublin, Ireland"},{"name":"Division of Population Health Sciences, Royal College of Surgeons, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shravya","family":"Govindappagari","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sbaa K.","family":"Syeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"D'Alton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.ajog.2005.11.008","article-title":"Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality","volume":"194","author":"A H James","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/asheducation-2016.1.413","article-title":"The post-thrombotic syndrome","volume":"2016","author":"S R Kahn","year":"2016","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7326\/0003-4819-149-10-200811180-00004","article-title":"Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis","volume":"149","author":"S R Kahn","year":"2008","journal-title":"Ann Intern Med"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/01.mcp.0000239543.40078.17","article-title":"Frequency and determinants of the postthrombotic syndrome after venous thromboembolism","volume":"12","author":"S R Kahn","year":"2006","journal-title":"Curr Opin Pulm Med"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.21037\/cdt.2018.01.09","article-title":"Chronic pulmonary embolism: diagnosis","volume":"8","author":"K H Nishiyama","year":"2018","journal-title":"Cardiovasc Diagn 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Haemost"},{"issue":"22","key":"ref9","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1056\/NEJMoa032274","article-title":"Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism","volume":"350","author":"V Pengo","year":"2004","journal-title":"N Engl J Med"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1739471.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T21:39:10Z","timestamp":1671485950000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1739471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":9,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,12,19]]},"published-print":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1739471","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,22]]}}}