{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:47Z","timestamp":1740126827943,"version":"3.37.3"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n            Objective\u2003The objective of this study was to examine temporal trends in the clinical presentation of patients diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnancy.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort study of pregnant women who were universally screened for SARS-CoV-2 and tested positive. This multi-center study of admissions to labor and delivery units in New York City and Long Island included all SARS-CoV-2-infected pregnant women admitted to labor and delivery units between April 10th and June 4th 2020. Six Northwell Health hospitals and Maimonides Medical Center were included in the study. The main measures of the study included patient reports of COVID-19 symptoms: fever, cough, chest pain, shortness of breath, nausea, vomiting, and intensive care unit (ICU) admissions. The main outcome measure was the percentage of all infected women who reported any of the above symptoms.<\/jats:p><jats:p>\n            Results\u2003In total, 427 infected pregnant women were included in the study. There was a statistically significant decline in the percentage of patients presenting with any symptoms over the course of the study. In addition, disease severity, symptoms of fever, cough, and chest pain\/shortness of breath also significantly declined over time, and no ICU admissions were noted after the third week of April.<\/jats:p><jats:p>\n            Conclusion\u2003There was a temporal shift away from symptomatic presentation in pregnant women diagnosed with SARS-CoV-2 over the course of the first months of the epidemic in New York. Further studies are necessary to elucidate the cause of this change in presentation among pregnant women, to determine whether this trend is also observed in other patient populations.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1739490","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:22:00Z","timestamp":1639704120000},"page":"1259-1264","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Trend in SARS-CoV-2 Symptoms in Pregnant Women"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-5281","authenticated-orcid":false,"given":"Viktoriya","family":"London","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Maimonides Medical Center, Brooklyn, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-6928","authenticated-orcid":false,"given":"Matthew J.","family":"Blitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, New York"},{"name":"Division of Maternal-Fetal Medicine, Southside Hospital, Bay Shore, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Solmonovich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, Brooklyn, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-7195","authenticated-orcid":false,"given":"Howard","family":"Minkoff","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Maimonides Medical Center, Brooklyn, New York"},{"name":"Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, Brooklyn, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","article-title":"Virological assessment of hospitalized patients with COVID-2019","volume":"581","author":"R W\u00f6lfel","year":"2020","journal-title":"Nature"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1055\/s-0040-1712164","article-title":"The relationship between status at presentation and outcomes among pregnant women with COVID-19","volume":"37","author":"V London","year":"2020","journal-title":"Am J Perinatol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"e1003209","DOI":"10.1371\/journal.ppat.1003209","article-title":"Evolution of virulence in emerging epidemics","volume":"9","author":"T W Berngruber","year":"2013","journal-title":"PLoS Pathog"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1017\/S003118201500092X","article-title":"The adaptive evolution of virulence: a review of theoretical predictions and empirical tests","volume":"143","author":"C E Cressler","year":"2016","journal-title":"Parasitology"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41576-018-0055-5","article-title":"The phylogenomics of evolving virus virulence","volume":"19","author":"J L Geoghegan","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ajog.2020.06.020","article-title":"Maternal mortality among women with coronavirus disease 2019 admitted to the intensive care unit","volume":"223","author":"M J Blitz","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"100212","DOI":"10.1016\/j.ajogmf.2020.100212","article-title":"Racial and ethnic disparity and spatiotemporal trends in severe acute respiratory syndrome coronavirus 2 prevalence on obstetrical units in New York","volume":"2","author":"M J Blitz","year":"2020","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"100349","DOI":"10.1016\/j.ajogmf.2021.100349","article-title":"Social determinants of health and coronavirus disease 2019 in pregnancy","volume":"3","author":"L Prasannan","year":"2021","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ajog.2020.05.035","article-title":"Delivery for respiratory compromise among pregnant women with coronavirus disease 2019","volume":"223","author":"R A McLaren Jr","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cell.2020.06.043","article-title":"Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus","volume":"182","author":"B Korber","year":"2020","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/d41586-020-02544-6","article-title":"The coronavirus is mutating - does it matter?","volume":"585","author":"E Callaway","year":"2020","journal-title":"Nature"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/cid\/ciu924","article-title":"Validation of the wild-type influenza A human challenge model H1N1pdMIST: an A(H1N1)pdm09 dose-finding investigational new drug study","volume":"60","author":"M J Memoli","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1128\/JVI.02009-15","article-title":"Characterization and demonstration of the value of a lethal mouse model of Middle East respiratory syndrome coronavirus infection and disease","volume":"90","author":"X Tao","year":"2015","journal-title":"J Virol"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.21037\/qims.2020.04.08","article-title":"Persistent viral shedding lasting over 60 days in a mild COVID-19 patient with ongoing positive SARS-CoV-2","volume":"10","author":"L Zhang","year":"2020","journal-title":"Quant Imaging Med Surg"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1739490.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:08:34Z","timestamp":1730804914000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1739490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,7,29]]},"published-print":{"date-parts":[[2023,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1739490","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published":{"date-parts":[[2021,12,16]]}}}