{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:14:12Z","timestamp":1776910452261,"version":"3.51.2"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003There is evidence that Chiari malformation (CM) and basilar invagination (BI) are largely due to disproportion between the content and volume of the posterior fossa. A recent study identified an increased association between brachycephaly and BI. In several types of craniosynostosis, the posterior fossa volume is smaller than normal, and this is more pronounced in coronal synostosis. The aim of this study is to evaluate the association between CM and BI.<\/jats:p><jats:p>\n          Methods\u2003The cephalic index (CI) measured on magnetic resonance imaging (MRI) from a sample of patients with craniocervical malformation was compared with that of normal subjects.<\/jats:p><jats:p>\n          Results\u2003The average CI in the craniovertebral junction malformation (CVJM) group was significantly higher in BI patients than in normal subjects. The BI patients also had the highest CI among the whole sample of patients (p\u2009=\u20090.009).<\/jats:p><jats:p>\n          Conclusions\u2003In this study, BI patients had the highest CI among patients with CVJM and a significantly higher CI than those in the control group. Our data confirm the association between BI and brachycephaly.<\/jats:p>","DOI":"10.1055\/s-0041-1739503","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T23:37:32Z","timestamp":1640043452000},"page":"329-333","source":"Crossref","is-referenced-by-count":7,"title":["Association between Brachycephaly, Chiari Malformation, and Basilar Invagination"],"prefix":"10.1055","volume":"84","author":[{"given":"Ricardo Vieira","family":"Botelho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Inst Assistencia Med Ao Serv Publ Estadual Sao Pa, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Bittencourt","family":"Botelho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculdade de medicina santa casa de sao paulo, S\u00e3o Paulo, 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bulbar symptoms in an adult: single-stage posterior fusion and foramen magnum decompression: a rare case report","volume":"15","author":"S C Balasubramanian","year":"2020","journal-title":"Asian J Neurosurg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejrad.2018.05.006","article-title":"Relationship between basilar invagination and brachycephaly in Northeastern Brazil","volume":"104","author":"J JC Nascimento","year":"2018","journal-title":"Eur J Radiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/j.wneu.2018.05.233","article-title":"Basilar invagination: a craniocervical kyphosis","volume":"117","author":"R V Botelho","year":"2018","journal-title":"World Neurosurg"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"e20190825","DOI":"10.1590\/0001-3765202020190825","article-title":"Where does the cranial base flexion take place in humans?","volume":"92","author":"R V 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Neurosurg"},{"issue":"02","key":"ref11","first-page":"197","article-title":"Roentgenological skull measurements and their diagnostic applications","volume":"67","author":"L L Haas","year":"1952","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.wneu.2020.02.182","article-title":"Posterior fossa dimensions of Chiari malformation patients compared with normal subjects: systematic review and meta-analysis","volume":"138","author":"R V Botelho","year":"2020","journal-title":"World Neurosurg"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3171\/jns.1997.86.1.0040","article-title":"Pathogenesis of Chiari malformation: a morphometric study of the posterior cranial fossa","volume":"86","author":"M Nishikawa","year":"1997","journal-title":"J Neurosurg"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.3174\/ajnr.A5810","article-title":"Imaging of clival hypoplasia in CHARGE syndrome and hypothesis for development: a case-control study","volume":"39","author":"C M de Geus","year":"2018","journal-title":"AJNR Am J Neuroradiol"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2214\/ajr.116.3.609","article-title":"Familial acrocephalosyndactyly (Pfeiffer syndrome)","volume":"116","author":"R M Saldino","year":"1972","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00381-008-0602-z","article-title":"Specific entities affecting the craniocervical region: osteogenesis imperfecta and related osteochondrodysplasias: medical and surgical management of basilar impression","volume":"24","author":"A H Menezes","year":"2008","journal-title":"Childs Nerv 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settling, and Chiari malformation type I in patients with hereditary disorders of connective tissue","volume":"7","author":"T H Milhorat","year":"2007","journal-title":"J Neurosurg Spine"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2011.6.FOCUS11112","article-title":"Associated disorders of Chiari type I malformations: a review","volume":"31","author":"M Loukas","year":"2011","journal-title":"Neurosurg Focus"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1227\/00006123-198809000-00013","article-title":"Arnold-Chiari malformation in an infant with Kleeblattschadel: an acquired malformation?","volume":"23","author":"J L Venes","year":"1988","journal-title":"Neurosurgery"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000028877","article-title":"Skull base growth in craniosynostosis","volume":"31","author":"S Sgouros","year":"1999","journal-title":"Pediatr 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