{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:45:44Z","timestamp":1770727544850,"version":"3.49.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"S 03","license":[{"start":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T00:00:00Z","timestamp":1640390400000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Patients with repaired complete atrioventricular septal defect (CAVSD) represent an increasing portion of grown-ups with congenital heart disease. For repair of CAVSD, the single-patch technique has been employed first. This technique requires division of the bridging leaflets, thus, among other issues, long-term function of the atrioventricular valves is of particular concern.<\/jats:p><jats:p>\n          Methods\u2003Between 1978 and 2001, 100 consecutive patients with isolated CAVSD underwent single-patch repair in our institution. Hospital mortality was 11%. Primary endpoints were clinical status, atrioventricular valve function, and freedom from reoperation in long term. Follow-up was obtained contacting the patient and\/or caregiver, and the referring cardiologist.<\/jats:p><jats:p>\n          Results\u2003Eighty-three patients were eligible for long-term follow-up (21.0\u2009\u00b1\u20098.7, mean\u2009\u00b1\u2009standard deviation [21.5; 2.1\u201340.0, median; min\u2013max] years after surgical repair). Actual long-term mortality was 3.4%. Quality of life (QoL; self- or caregiver-reported in patients with Down syndrome) was excellent or good in 81%, mild congestive heart failure was present in 16%, moderate in 3.6% as estimated by New York Heart Association classification. Echocardiography revealed normal systolic left ventricular function in all cases. Regurgitation of the right atrioventricular valve was mild in 48%, mild\u2013moderate in 3.6%, and moderate in 1.2%. The left atrioventricular valve was mildly stenotic in 15% and mild to moderately stenotic in 2%; regurgitation was mild in 54%, mild to moderate in 13%, and moderate in 15% of patients. Freedom from left atrioventricular-valve-related reoperation was 95.3, 92.7, and 89.3% after 5, 10, and 30 years, respectively. Permanent pacemaker therapy, as an immediate result of CAVSD repair (n\u2009=\u20097) or as a result of late-onset sick sinus syndrome (n\u2009=\u20095), required up to six reoperations in single patients. Freedom from pacemaker-related reoperation was 91.4, 84.4, and 51.5% after 5, 10, and 30 years, respectively.<\/jats:p><jats:p>\n          Conclusion\u2003Up to 40 years after single-patch repair of CAVSD, clinical status and functional results are promising, particularly, in terms of atrioventricular valve function. Permanent pacemaker therapy results in a life-long need for surgical reinterventions.<\/jats:p>","DOI":"10.1055\/s-0041-1740070","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T23:33:28Z","timestamp":1640475208000},"page":"e68-e75","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Long-Term Outcome Up To 40 Years after Single Patch Repair of Complete Atrioventricular Septal Defect in Infancy or Childhood"],"prefix":"10.1055","volume":"69","author":[{"given":"Stefanie","family":"Reynen","sequence":"first","affiliation":[{"name":"Department of Surgery for Congenital Heart Disease, RWTH Aachen University, Aachen, Germany"},{"name":"Department of Internal Medicine II (Cardiology), University Hospital Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedwig H.","family":"H\u00f6vels-G\u00fcrich","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, RWTH Aachen University, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime F.","family":"Vazquez-Jimenez","sequence":"additional","affiliation":[{"name":"Department of Surgery for Congenital Heart Disease, RWTH Aachen University, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno J.","family":"Messmer","sequence":"additional","affiliation":[{"name":"Department of Surgery for Congenital Heart Disease, RWTH Aachen University, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg S.","family":"Sachweh","sequence":"additional","affiliation":[{"name":"Department of Surgery for Congenital Heart Disease, RWTH Aachen University, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,25]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1055\/s-0030-1254155","article-title":"Prevalence of congenital heart defects in newborns in Germany: results of the first registration year of the PAN Study (July 2006 to June 2007)","volume":"222","author":"A Lindinger","year":"2010","journal-title":"Klin Padiatr"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8","article-title":"Population-based study of congenital heart defects in Down syndrome","volume":"80","author":"S B Freeman","year":"1998","journal-title":"Am J Med Genet"},{"issue":"01","key":"ref3","first-page":"11","article-title":"The direct-vision intracardiac correction of congenital anomalies by controlled cross circulation; results in thirty-two patients with ventricular septal defects, tetralogy of Fallot, and atrioventricularis communis defects","volume":"38","author":"C W Lillehei","year":"1955","journal-title":"Surgery"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0022-5223(20)31630-5","article-title":"The surgical treatment of common atrioventricular canal","volume":"43","author":"J V Maloney Jr","year":"1962","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0022-5223(19)40256-0","article-title":"Discussion of Mills NL, Ochsner JL, King TD. Correction of type C complete atrioventricular canal. Surgical considerations","volume":"71","author":"G A Trusler","year":"1976","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0003-4975(97)00566-3","article-title":"Anatomically sound, simplified approach to repair of \u201ccomplete\u201d atrioventricular septal defect","volume":"64","author":"B R Wilcox","year":"1997","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0022-5223(99)70009-7","article-title":"Simplified single patch technique for the repair of atrioventricular septal defect","volume":"118","author":"I A Nicholson","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jtcvs.2015.05.011","article-title":"Long-term outcomes after surgical repair of complete atrioventricular septal defect","volume":"150","author":"S Ginde","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0003-4975(01)03170-8","article-title":"Surgical repair of complete atrioventricular septal defect","volume":"72","author":"F A Crawford Jr","year":"2001","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1352\/1944-7558-121.4.312","article-title":"Measuring health-related quality of life of adults with Down syndrome","volume":"121","author":"R J Graves","year":"2016","journal-title":"Am J Intellect Dev Disabil"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0022-5223(19)36222-1","article-title":"Actuarial survival, freedom from reoperation, and other events after repair of atrioventricular septal defects","volume":"94","author":"L B McGrath","year":"1987","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0003-4975(98)00028-9","article-title":"Long-term results after repair of complete atrioventricular septal defects: analysis of risk factors","volume":"65","author":"T G\u00fcnther","year":"1998","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.athoracsur.2018.02.086","article-title":"Long-term outcome after pulmonary artery banding in children with atrioventricular septal defects","volume":"106","author":"E Buratto","year":"2018","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.athoracsur.2009.11.017","article-title":"Long-term results after repair of complete atrioventricular septal defect with two-patch technique","volume":"89","author":"F Bakhtiary","year":"2010","journal-title":"Ann Thorac 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Surg"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/s-2006-924627","article-title":"Mechanical aortic and mitral valve replacement in infants and children","volume":"55","author":"J S Sachweh","year":"2007","journal-title":"Thorac Cardiovasc Surg"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jtcvs.2007.04.025","article-title":"Replacement of the systemic atrioventricular valve with a mechanical prosthesis in children aged less than 6 years: late clinical results of survival and subsequent replacement","volume":"134","author":"K Ackermann","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/icvts\/ivr088","article-title":"Long-term self-management of anticoagulation therapy after mechanical heart valve replacement in outside trial conditions","volume":"14","author":"H Mair","year":"2012","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"08","key":"ref25","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1007\/s00246-018-1934-4","article-title":"Bradyarrhythmias in repaired atrioventricular septal defects: single-center experience based on 34 years of follow-up of 522 patients","volume":"39","author":"C Di Mambro","year":"2018","journal-title":"Pediatr Cardiol"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.athoracsur.2015.01.032","article-title":"Modified single patch: are we still worried about subaortic stenosis?","volume":"99","author":"C L Backer","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/j.pcsu.2014.01.008","article-title":"Reoperation for left ventricular outflow tract obstruction after repair of atrioventricular septal","volume":"17","author":"D M 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