{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:46Z","timestamp":1740126826288,"version":"3.37.3"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n            Objective\u2003The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS).<\/jats:p><jats:p>\n            Study Design\u2003One-hundred twenty term neonates along with their mothers were enrolled in this case\u2013control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48\u2009hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts.<\/jats:p><jats:p>\n            Results\u2003Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1\u2009ng\/mL, respectively) were significantly lower than in controls (22.7 and 21\u2009ng\/mL, respectively) p\u2009=\u20090.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r\u2009=\u2009\u22120.616 and \u22120.596, respectively) p &lt;0.001 for both. With a cut-off value of 12.9\u2009ng\/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI\u2009=\u20091.034\u20131.144)) for LOS in vitamin D-deficient neonates.<\/jats:p><jats:p>\n            Conclusion\u2003Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1740074","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T23:31:51Z","timestamp":1638142311000},"page":"143-149","source":"Crossref","is-referenced-by-count":3,"title":["Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case\u2013Control Study"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-7209","authenticated-orcid":false,"given":"Shaimaa Reda","family":"Abdelmaksoud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Benha Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa Abdel-Azim","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Benha Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-4382","authenticated-orcid":false,"given":"Rana Atef","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Chemistry, Benha Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Effat","family":"Assar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Benha Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","article-title":"Neonatal sepsis","volume":"390","author":"A L 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