{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:38:04Z","timestamp":1778755084149,"version":"3.51.4"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Sinonasal melanomas are rare tumors with no comparative survival studies between Europe and the US.<\/jats:p><jats:p>\n          Objective\u2003To provide a population-based survival analysis between the two continents.<\/jats:p><jats:p>\n          Methods\u2003The European Cancer Registry (EUROCARE) and the United States Surveillance, Epidemiology, and End Results (SEER) databases were queried to identify patients diagnosed with sinonasal melanoma between 2000 and 2007. Relative survival (RS) data were grouped by age, gender, geographic region, extent of disease, and treatment modality.<\/jats:p><jats:p>\n          Results\u2003A total of 1,294 cases were identified between 2000 and 2007 (935 from EUROCARE-5 and 359 from SEER). Females were most commonly identified in Europe (56.4%) and in the US (54.9%). Patients over the age of 65 years comprised the greatest proportion of patients in Europe (70%) and in the US (71%). By region, Southern Europe had the highest 5-year RS (31.6%, 95% confidence interval [CI]\u2009=\u2009[21.3\u201342.5%]), and Eastern Europe the lowest (16.5%, [7.5\u201328.5%]). The aggregate European 5-year RS was 25.4% [21.8\u201329.1%] and the U.S. was (29.7%, [23.6\u201336%]).<\/jats:p><jats:p>\n          Conclusions\u2003Although increasing in incidence, sinonasal melanomas remain rare. Women were more commonly affected. The most common age group was those older than 65 years, although age did not confer a prognostic value. The most common subsite was the nasal cavity followed by the maxillary sinus. Five-year RS was similar between continents with an inverse relationship between extent of disease and survival. The treatment of choice throughout Europe and the US remains primarily surgical.<\/jats:p>","DOI":"10.1055\/s-0041-1740099","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T01:13:21Z","timestamp":1643332401000},"page":"e446-e452","source":"Crossref","is-referenced-by-count":8,"title":["Sinonasal Mucosal Melanoma: A Population-based Comparison of the EUROCARE and SEER Registries"],"prefix":"10.1055","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-7132","authenticated-orcid":false,"given":"David","family":"Temmermand","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Augusta University, Augusta, GA, United States"},{"name":"Department of Otolaryngology & Facial Plastic Surgery, Rowan University School of Osteopathic Medicine, Stratford, NJ, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suat","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Mikhael","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-8260","authenticated-orcid":false,"given":"Jennifer","family":"Butler","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Augusta University, Augusta, GA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aykut A.","family":"Unsal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and 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Stern","year":"1991","journal-title":"Head Neck"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/ijc.28625","article-title":"Epidemiology and survival outcomes of ocular and mucosal melanomas: a population-based analysis","volume":"134","author":"K D Bishop","year":"2014","journal-title":"Int J Cancer"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1470-2045(13)70546-1","article-title":"Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE\u20135-a population-based study","volume":"15","author":"R De Angelis","year":"2014","journal-title":"Lancet Oncol"},{"key":"ref5","volume-title":"Cancer survival trends in England and Wales, 1971\u20131995: deprivation and NHS region","author":"M P Coleman","year":"1999"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hed.10019","article-title":"Primary mucosal malignant melanoma of the head and 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Samstein","year":"2016","journal-title":"Head Neck"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/alr.21831","article-title":"The presentation and outcomes of mucosal melanoma in 695 patients","volume":"7","author":"N Konuthula","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G","article-title":"The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade","volume":"83","author":"A E Chang","year":"1998","journal-title":"Cancer"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12105-017-0789-y","article-title":"Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Mucosal Melanomas","volume":"11","author":"M D 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