{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T04:50:46Z","timestamp":1758862246656},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Colon Rectal Surg"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Necrotizing soft tissue infections of the perineum are rapidly progressing infections associated with significant morbidity and mortality. Prompt diagnosis and management with early surgical debridement is necessary to improve survival from this deadly disease. Repeat debridements are not uncommon. Important adjuncts to surgery include broad-spectrum antibiotics and management in an intensive care unit, as patients frequently develop multisystem organ failure. Once the acute phase is managed, fecal diversion with either an ostomy or fecal management catheter can be considered to decrease soiling of the wound and facilitate healing. Long-term management requires meticulous wound care, often with the assistance of negative pressure wound therapy. Patients may ultimately require skin grafts or tissue flaps for soft tissue coverage following extensive surgical debridements.<\/jats:p>","DOI":"10.1055\/s-0041-1740102","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T23:55:01Z","timestamp":1644450901000},"page":"237-243","source":"Crossref","is-referenced-by-count":5,"title":["Necrotizing Soft Tissue Infections of the Perineum"],"prefix":"10.1055","volume":"35","author":[{"given":"Bryan P.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimalan A.","family":"Jeganathan","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/MCC.0b013e32825a6a1b","article-title":"Necrotizing soft tissue infections","volume":"13","author":"M Cainzos","year":"2007","journal-title":"Curr Opin Crit Care"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jamcollsurg.2008.10.032","article-title":"Necrotizing fasciitis: current concepts and review of the literature","volume":"208","author":"B Sarani","year":"2009","journal-title":"J Am Coll Surg"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.idc.2017.05.011","article-title":"Evaluation and management of necrotizing soft tissue infections","volume":"31","author":"S L Bonne","year":"2017","journal-title":"Infect Dis Clin North Am"},{"volume-title":"Surgical Memoirs of the War of the Rebellion: Investigation upon the Nature, Causes and Treatment of Hospital Gangrene as Prevailed in the Confederate Armies 1861\u20131865","year":"1871","author":"J Jones","key":"ref4"},{"key":"ref5","first-page":"589","volume-title":"Gangr\u00e8ne foudroyante de la verge. 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