{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:57:57Z","timestamp":1740142677848,"version":"3.37.3"},"reference-count":46,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"12","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Gestational hypertension (GH) is characterized by increased blood pressure after the 20th gestational week; the presence of proteinuria and\/or signs of end-organ damage indicate preeclampsia (PE). Heme oxygenase-1 (HO-1) is an antioxidant enzyme with an important role in maintaining endothelial function, and induction of HO-1 by certain molecules shows potential in attenuating the condition's effects over endothelial tissue. HO-1 production can also be stimulated by potassium iodide (KI). Therefore, we evaluated the effects of KI over HO-1 expression in human umbilical vein endothelial cells (HUVECs) incubated with plasma from women diagnosed with GH or PE.<\/jats:p><jats:p>\n          Methods\u2003Human umbilical vein endothelial cells were incubated with a pool of plasma of healthy pregnant women (n\u2009=\u200912), pregnant women diagnosed with GH (n\u2009=\u200910) or preeclamptic women (n\u2009=\u200911) with or without the addition of KI for 24\u2009hours to evaluate its effect on this enzyme expression. Analysis of variance was performed followed by Dunnet's test for multiple comparisons between groups only or between groups with addition of KI (p \u2264 0.05).<\/jats:p><jats:p>\n          Results\u2003KI solution (1,000 \u00b5M) reduced HO-1 in the gestational hypertension group (p\u2009=\u20090.0018) and cytotoxicity in the preeclamptic group (p\u2009=\u20090.0143); treatment with KI reduced plasma cytotoxicity but did not affect the preeclamptic group's HO-1 expression.<\/jats:p><jats:p>\n          Conclusion\u2003Our findings suggest that KI alleviates oxidative stress leading to decreased HO-1 expression; plasma from preeclamptic women did not induce the enzyme's expression in HUVECs, and we hypothesize that this is possibly due to inhibitory post-transcriptional mechanisms in response to overexpression of this enzyme during early pregnancy.<\/jats:p>","DOI":"10.1055\/s-0041-1740270","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T23:32:30Z","timestamp":1640129550000},"page":"894-903","source":"Crossref","is-referenced-by-count":1,"title":["Preeclampsia and Gestational Hypertension: Biochemical and Antioxidant Features in Vitro Might Help Understand Different Outcomes"],"prefix":"10.61622","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-5182","authenticated-orcid":false,"given":"Victoria Elizabeth","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Instituto de Bioci\u00eancias, Universidade Estadual Paulista, Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-4914","authenticated-orcid":false,"given":"Ricardo Carvalho","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-7470","authenticated-orcid":false,"given":"Valeria Cristina","family":"Sandrim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Instituto de Bioci\u00eancias, Universidade Estadual Paulista, Botucatu, SP, Brazil"},{"name":"Center for Toxicological Assistance, Instituto de Bioci\u00eancias, Universidade Estadual Paulista, Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","article-title":"Gynecologists' Task Force on Hypertension in Pregnancy Hypertension in pregnancy","volume":"122","author":"American College of 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