{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:29:57Z","timestamp":1785846597362,"version":"3.56.0"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003O \u00e1cido tranex\u00e2mico (TXA) \u00e9 um antifibrinol\u00edtico amplamente utilizado para diminuir as taxas de perda de sangue e de transfus\u00e3o de sangue na artroplastia total do quadril. No entanto, h\u00e1 evid\u00eancias limitadas de uso t\u00f3pico de TXA na hemiartroplastia do quadril para fraturas no pesco\u00e7o femoral. O presente estudo teve como objetivo avaliar os efeitos do TXA t\u00f3pico na perda de sangue e transfus\u00f5es de sangue em pacientes com fratura femoral que foram submetidos a hemiartroplastia bipolar cimentada.<\/jats:p><jats:p>\n          M\u00e9todos\u2003Vinte e seis pacientes com fraturas no pesco\u00e7o femoral e programados para artroplastia cimentada bipolar foram randomizados em dois grupos. O primeiro grupo de 12 pacientes recebeu TXA t\u00f3pico durante a opera\u00e7\u00e3o; no segundo grupo, 14 pacientes receberam placebo. O hemat\u00f3crito foi medido \u00e0s 6 e 24 horas no p\u00f3s-operat\u00f3rio. Tamb\u00e9m foram registradas transfus\u00f5es de sangue e complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias.<\/jats:p><jats:p>\n          Resultados\u2003A perda total de sangue n\u00e3o foi diferente entre o grupo TXA e o grupo controle (grupo TXA: 459,48\u2009\u00b1\u2009456,32\u2009ml; e grupo controle: 732,98\u2009\u00b1\u2009474,02\u2009ml; p\u2009=\u20090,14). No entanto, n\u00e3o houve pacientes dentro do grupo TXA que necessitaram de transfus\u00e3o de sangue, enquanto 4 pacientes no grupo controle fizeram transfus\u00f5es de sangue halog\u00eanicas (p\u2009=\u20090,044). N\u00e3o houve complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias, tais como complica\u00e7\u00e3o da ferida, tromboembolismo venoso ou complica\u00e7\u00f5es cardiovasculares dentro de qualquer grupo.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003O TXA t\u00f3pico n\u00e3o conseguiu diminuir a perda total de sangue, mas foi capaz de reduzir as taxas de transfus\u00e3o, em pacientes submetidos a hemiartroplastia de quadril bipolar cimentada em fraturas no pesco\u00e7o femoral. Outros estudos com doses de TXA t\u00f3pico em um tamanho amostral maior seriam ben\u00e9ficos.<\/jats:p><jats:p>\n          N\u00edvel de Evid\u00eancia\u2003II.<\/jats:p>","DOI":"10.1055\/s-0041-1740292","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T23:41:20Z","timestamp":1640043680000},"page":"240-245","source":"Crossref","is-referenced-by-count":2,"title":["A efic\u00e1cia do \u00e1cido tranex\u00e2mico t\u00f3pico em pacientes com fraturas no pesco\u00e7o femoral submetidos a hemiartroplastia bipolar cimentada: Um ensaio controlado duplo-cego randomizado"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-0222","authenticated-orcid":false,"given":"Theerawit","family":"Hongnaparak","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, Faculdade de Medicina, Universidade Pr\u00edncipe da Songkla, Tail\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1816-3652","authenticated-orcid":false,"given":"Fatin","family":"Binlateh","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, Faculdade de Medicina, Universidade Pr\u00edncipe da Songkla, Tail\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-6742","authenticated-orcid":false,"given":"Khanin","family":"Iamthanaporn","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, Faculdade de Medicina, Universidade Pr\u00edncipe da Songkla, Tail\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-4197","authenticated-orcid":false,"given":"Pramot","family":"Tanutit","sequence":"additional","affiliation":[{"name":"Departamento de Radiologia, Faculdade de Medicina, Universidade Pr\u00edncipe da Songkla, Songkhla, Tail\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-7733","authenticated-orcid":false,"given":"Varah","family":"Yuenyongviwat","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, Faculdade de Medicina, Universidade Pr\u00edncipe da Songkla, Tail\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"e024350","DOI":"10.1136\/bmjopen-2018-024350","article-title":"Comparison of intravenous, topical or combined routes of tranexamic acid administration in patients undergoing total knee and hip arthroplasty: a meta-analysis of randomised controlled trials","volume":"9","author":"Q Sun","year":"2019","journal-title":"BMJ 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