{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:08:06Z","timestamp":1789697286562,"version":"4.0.1"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                  Objective\u2003Preeclampsia (PE) is a pregnancy-specific condition featured by high blood pressure, edema, and proteinuria. Research about the role of microRNA (miR)-203 in PE remains insufficient. This experiment is designed to investigate the specific role of miR-203 in trophoblasts in PE.<\/jats:p><jats:p>\n                  Study Design\u2003miR-203 expression in placenta tissues of normal pregnant women and PE patients was examined to analyze the relevance between miR-203 and PE diagnostic efficiency and between miR-203 and blood pressure (systolic pressure and diastolic pressure) and proteinuria of PE patients. miR-203 expression was downregulated in hypoxia-cultured trophoblasts using miR-203 inhibitor to assess matrix metalloproteinase-9 (MMP-9) level. Then, the angiogenesis of trophoblasts with different treatments was determined. Subsequently, the target relation between miR-203 and insulin-like growth factor receptor 1 (IGF-1R) was predicted and verified. Additionally, the effect of IGF-1R in the mechanism of miR-203 modulating trophoblast vascular remodeling was detected.<\/jats:p><jats:p>\n                  Results\u2003miR-203 was overexpressed in the placenta of PE patients and it acted as a promising diagnostic indicator for PE. Moreover, miR-203 was positively associated with blood pressure (systolic pressure and diastolic pressure) and proteinuria of PE patients. miR-203 silencing in hypoxia-cultured trophoblasts enhanced trophoblast vascular remodeling. Mechanically, miR-203 bound to IGF-1R to suppress its transcription. IGF-1R downregulation counteracted the promotive effect of miR-203 silencing on trophoblast vascular remodeling.<\/jats:p><jats:p>\n                  Conclusion\u2003miR-203 was overexpressed in PE, and it targeted IGF-1R to limit trophoblast vascular remodeling.<\/jats:p><jats:p>\n                  Key Points\n               <\/jats:p>","DOI":"10.1055\/s-0041-1740300","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:05:49Z","timestamp":1639181149000},"page":"355-364","source":"Crossref","is-referenced-by-count":1,"title":["microRNA-203 Targets Insulin-Like Growth Factor Receptor 1 to Inhibit Trophoblast Vascular Remodeling to Augment Preeclampsia"],"prefix":"10.1055","volume":"41","author":[{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal and Child health Hospital of Hubei Province, Wuhan City, Hubei Province, People's Republic of 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