{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:32:17Z","timestamp":1780101137976,"version":"3.54.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preventing hemorrhage progression is a potential therapeutic opportunity in traumatic brain injury (TBI) management, but its use has been limited by fear of provoking vascular occlusive events (VOEs). However, it is currently unclear whether VOE actually affects outcome in these patients. The aim of this study was to determine incidence, risk factors, and clinical significance of VOE in patients with moderate-to-severe TBI. A retrospective observational cohort study of adults (\u226515 years) with moderate-to-severe TBI was performed. The presence of a VOE during hospitalization was noted from hospital charts and radiological reports. Functional outcome, using the Glasgow Outcome Scale (GOS), was assessed at 12 months posttrauma. Univariate and multivariate logistic regressions were used for endpoint assessment. In total, 848 patients were included, with a median admission Glasgow Coma Scale of 7. A VOE was detected in 54 (6.4%) patients, of which cerebral venous thrombosis was the most common (3.2%), followed by pulmonary embolism (1.7%) and deep vein thrombosis (1.3%). Length of ICU stay (p\u2009&lt;\u20090.001), body weight (p\u2009=\u20090.002), and skull fracture (p\u2009=\u20090.004) were independent predictors of VOE. VOE development did not significantly impact 12-month GOS, even after adjusting for potential confounders using propensity score matching. In conclusion, VOE in moderate-to-severe TBI patients was relatively uncommon, and did not affect 12-month GOS. This suggests that the potential benefit of treating bleeding progression might outweigh the risks of VOE.<\/jats:p>","DOI":"10.1055\/s-0041-1740567","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T23:35:27Z","timestamp":1641512127000},"page":"301-308","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Significance of Vascular Occlusive Events following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study"],"prefix":"10.1055","volume":"48","author":[{"given":"Alexander","family":"Fletcher-Sandersj\u00f6\u00f6","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Tatter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Tjerkaski","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Bartek Jr","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Peter","family":"Thelin","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Michael","family":"Bellander","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3171\/2009.5.JNS081369","article-title":"The natural history of brain contusion: an analysis of radiological and clinical 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