{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:27:10Z","timestamp":1775863630790,"version":"3.50.1"},"reference-count":20,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Introduction<\/jats:bold>\u2003Subacute sclerosing panencephalitis (SSPE) is a devastating neurodegenerative disease occurring as a complication of measles infection that is still prevalent in low-resource countries. Clinical and electrographical variability in SSPE can lead to diagnostic delays.<\/jats:p>\n<jats:p>\n<jats:bold>Methods<\/jats:bold>\u2003Children diagnosed with SSPE in a tertiary care pediatric hospital in India in a period of 8 years were included in the study. The diagnosis was established on the basis of Dyken's criteria. The demographic data, clinical presentations, investigations, treatment approaches, and outcomes were reviewed and recorded.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003Thirty-four patients were included in the analysis. Average age at symptom onset was 7 years, 5 months. Majority of the children were not vaccinated for measles. Most patients (80%) presented with stage 2 of illness. Nearly 25% presented with atypical clinical features. Myoclonus was the most predominant feature seen after diagnosis. Electroencephalography (EEG) was the most useful investigation for suspecting the diagnosis. All patients showed deterioration in neurological status with time and 20% died during follow-up.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003Atypical presentations of SSPE must be recognized in areas with high incidence to institute timely treatment and establish prognosis. EEG findings were found to be the most important indicator for diagnosis. Measles eradication will pave the way for elimination of this dreaded disease.<\/jats:p>","DOI":"10.1055\/s-0041-1740612","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T23:59:23Z","timestamp":1644537563000},"page":"315-320","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Subacute Sclerosing Panencephalitis (SSPE): Experience from a Tertiary-Care Pediatric Center"],"prefix":"10.25259","volume":"13","author":[{"given":"Meenal","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Surya Hospitals, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshita","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa D.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anaita Udwadia","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnakumar N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"issue":"12","key":"10.1055\/s-0041-1740612\/ref-1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s00415-008-0032-6","article-title":"Subacute sclerosing panencephalitis","volume":"255","author":"Garg","year":"2008","journal-title":"J Neurol"},{"issue":"10","key":"10.1055\/s-0041-1740612\/ref-2","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1086\/497169","article-title":"Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized","volume":"192","author":"Bellini","year":"2005","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1055\/s-0041-1740612\/ref-3","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/ije\/dym207","article-title":"Review of the effect of measles vaccination on the epidemiology of SSPE","volume":"36","author":"Campbell","year":"2007","journal-title":"Int J Epidemiol"},{"issue":"3","key":"10.1055\/s-0041-1740612\/ref-4","first-page":"295","article-title":"Atypical presentations of SSPE: a clinical study in four cases","volume":"49","author":"Demir","year":"2007","journal-title":"Turk J Pediatr"},{"issue":"1","key":"10.1055\/s-0041-1740612\/ref-5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0733-8619(18)31062-4","article-title":"Subacute sclerosing panencephalitis. 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