{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:54:16Z","timestamp":1771998856436,"version":"3.50.1"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Numerous methods have been described to repair nasal cerebrospinal fluid (CSF) leaks. Most studies have focused on optimizing CSF leak repair success, leading to closure rates of 90 to 95%.<\/jats:p><jats:p>\n          Objective\u2003This study aimed to determine if excellent reconstruction rates could be achieved without using sinonasal packing.<\/jats:p><jats:p>\n          Methods\u2003A prospective case series of 73 consecutive patients with various CSF leak etiologies and skull base defects was conducted to evaluate reconstruction success without sinonasal packing. The primary outcome measure was postoperative CSF leak. Secondary outcome measures were postoperative epistaxis requiring intervention in operating room or emergency department, infectious sinusitis, and 22-item sinonasal outcome test (SNOT-22) changes.<\/jats:p><jats:p>\n          Results\u2003Mean age was 54.5 years and 64% were female. Multilayered reconstructions were performed in 55.3% of cases, with collagen or bone epidural inlay grafts, and nasal mucosal grafts or nasoseptal flaps for onlay layers. Onlay-only reconstructions with mucosal grafts or nasoseptal flaps were performed in 44.7% of cases. Tissue sealants were used in all cases, and lumbar drains were used in 40.8% of cases. There were two initial failures (97.4% initial success), but both resolved with lumbar drains alone (no revision surgeries). There were no instances of postoperative epistaxis requiring intervention in the operating room or emergency department. Infectious sinusitis occurred in 2.7% of patients in the first 3 months postoperatively. SNOT-22 did not change significantly from preoperatively to first postoperative visits, then improved over time.<\/jats:p><jats:p>\n          Conclusion\u2003Nasal CSF leaks from various etiologies and defect sites were successfully repaired without using sinonasal packing, and patients experienced minimal sinonasal morbidity.<\/jats:p>","DOI":"10.1055\/s-0041-1740622","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T01:24:53Z","timestamp":1639790693000},"page":"476-484","source":"Crossref","is-referenced-by-count":4,"title":["Sinonasal Packing is Not a Requisite for Successful Cerebrospinal Fluid Leak Repair"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2084-4863","authenticated-orcid":false,"given":"Karam","family":"Asmaro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Henry Ford Health System, Detroit, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulkader","family":"Yassin-Kassab","sequence":"additional","affiliation":[{"name":"Michigan State University College of Human Medicine, East Lansing, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bazydlo","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Robin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack P.","family":"Rock","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Henry Ford Health System, Detroit, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3171\/2017.11.JNS172141","article-title":"Evolution of the graded repair of CSF leaks and skull base defects in endonasal endoscopic tumor surgery: trends in repair failure and meningitis rates in 509 patients","volume":"130","author":"A Conger","year":"2018","journal-title":"J Neurosurg"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/ons\/opy219","article-title":"Abdominal fat graft for sellar reconstruction: retrospective outcomes review and technical note","volume":"16","author":"E Roca","year":"2019","journal-title":"Oper Neurosurg (Hagerstown)"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/00005537-200007000-00019","article-title":"Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea: a meta-analysis","volume":"110","author":"H M Hegazy","year":"2000","journal-title":"Laryngoscope"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3171\/2010.10.JNS09406","article-title":"Endoscopic endonasal skull base surgery: analysis of complications in the authors' initial 800 patients","volume":"114","author":"A B Kassam","year":"2011","journal-title":"J Neurosurg"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1097\/01.mlg.0000234933.37779.e4","article-title":"A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap","volume":"116","author":"G Hadad","year":"2006","journal-title":"Laryngoscope"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/0194599814520685","article-title":"Endoscopic reconstruction of surgically created skull base defects: a systematic review","volume":"150","author":"E Soudry","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/lary.22475","article-title":"Endoscopic skull base reconstruction of large dural defects: a systematic review of published evidence","volume":"122","author":"R J Harvey","year":"2012","journal-title":"Laryngoscope"},{"key":"ref8","first-page":"1","article-title":"Does lumbar drainage reduce postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery? 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