{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:00:43Z","timestamp":1788404443558,"version":"build-2803163510"},"reference-count":89,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"La Fondazione Anticorpi Antifosfolipidi ONLUS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim\u2003To evaluate the relevance of plasma homocysteine (HC) in Behcet's disease (BD) and its clinical manifestations.<\/jats:p><jats:p>\n          Methods\u2003Systematic review of EMBASE and PubMed databases according to PRISMA guidelines from inception to July 2021; random-effects meta-analyses for continuous outcomes.<\/jats:p><jats:p>\n          Results\u2003The search strategy retrieved 48 case\u2013control (2,669 BD and 2,245 control participants) and 5 cohort studies (708 BD participants). Plasma HC was higher in BD than in controls (p\u2009&lt;\u20090.0001) with wide heterogeneity (I2\n          \u2009=\u200989.7%) that remained unchanged after sensitivity analysis according to year of article publication, age of BD participants, study size, study quality, method of HC determination, and male\/female ratio &gt;1.5; some pooled ethnicities explained a small part of the heterogeneity (I2\n          \u2009=\u200916.3%). Active BD participants had higher HC than inactive ones (p\u2009&lt;\u20090.0001), with moderate heterogeneity (I2\n          \u2009=\u200949.2%) that disappeared after removal of an outlier study with very high disease activity. BD participants with any vascular involvement had higher HC than those without (p\u2009&lt;\u20090.0001) with wide heterogeneity (I2\n          \u2009=\u200989.7%); subgroup analysis on venous thrombosis only changed neither effect size (p\u2009&lt;\u20090.0001) nor heterogeneity (I2\n          \u2009=\u200972.7%). BD participants with ocular involvement had higher HC than those without (p\u2009&lt;\u20090.0001) with moderate heterogeneity (I2\n          \u2009=\u200940.3%).<\/jats:p><jats:p>\n          Conclusion\u2003Although causality cannot be inferred, the consistency of the elevation of plasma HC in BD, particularly in patients with active disease, with vascular and ocular involvement suggests an intrinsic involvement of HC in these clinical manifestations.<\/jats:p>","DOI":"10.1055\/s-0041-1740637","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T23:35:25Z","timestamp":1641598525000},"page":"1209-1220","source":"Crossref","is-referenced-by-count":8,"title":["Plasma Homocysteine in Behcet's Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"122","author":[{"given":"Mira","family":"Merashli","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, American University of Beirut, Bliss, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Surgical Specialties and Organ Transplantation \u201cParide Stefanini,\u201d Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Pastori","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pignatelli","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Arcaro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u2018V. Tiberio\u2019, Universit\u00e0 del Molise, Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u2018V. Tiberio\u2019, Universit\u00e0 del Molise, Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Marottoli","sequence":"additional","affiliation":[{"name":"Multimedica SRL, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0165-9651","authenticated-orcid":false,"given":"Paul R. 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