{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:57:32Z","timestamp":1782734252804,"version":"3.54.5"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003Verificar como a administra\u00e7\u00e3o conjunta de alendronato de s\u00f3dio (ALN) e vitamina D3 (VD) atua na microarquitetura \u00f3ssea em ratas com osteoporose induzida por glicocorticoide.<\/jats:p><jats:p>\n          M\u00e9todos\u2003O experimento utilizou 32 ratas da linhagem Wistar, com peso m\u00e9dio de 300 a 400g, com 90 dias de vida. A indu\u00e7\u00e3o da osteoporose consistiu na administra\u00e7\u00e3o de dexametasona na dose de 7,5\u2009mg\/kg de peso corporal, por via intramuscular, 1 vez por semana durante 5 semanas, \u00e0 exce\u00e7\u00e3o dos animais do grupo controle. Os animais foram distribu\u00eddos nos seguintes grupos: G1 (grupo controle sem osteoporose), G2 (grupo controle com osteoporose sem tratamento), G3 (grupo com osteoporose tratado com ALN 0,2\u2009mg\/kg), G4 (grupo com osteoporose tratado com VD 10.000UI\/500\u03bcL) e G5 (grupo com osteoporose tratado com ALN\u2009+\u2009VD). Os f\u00eamures direitos das ratas foram fixados em formol a 10% tamponado, descalcificados e processados para inclus\u00e3o em parafina. Os cortes histol\u00f3gicos foram corados com hematoxilina-eosina para an\u00e1lise histomorfom\u00e9trica. A espessura cortical e a cavidade medular foram medidas em cortes transversais.<\/jats:p><jats:p>\n          Resultados\u2003Houve diferen\u00e7a estat\u00edstica (p\u2009&lt;\u20090,05) entre os grupos G3 e G5 em rela\u00e7\u00e3o ao grupo controle positivo (G2), tanto em rela\u00e7\u00e3o \u00e0 medida da espessura cortical quanto em rela\u00e7\u00e3o ao di\u00e2metro total do osso. Na avalia\u00e7\u00e3o da \u00e1rea medular, apenas o grupo G3 se mostrou estatisticamente diferente do grupo G2.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003O tratamento concomitante com ALN di\u00e1rio e VD semanal \u00e9 eficaz para prevenir a perda \u00f3ssea induzida por glicocorticoide. No entanto, n\u00e3o houve diferen\u00e7a entre esta terapia testada e o tratamento apenas com o ALN.<\/jats:p>","DOI":"10.1055\/s-0041-1741023","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T23:42:18Z","timestamp":1647042138000},"page":"267-272","source":"Crossref","is-referenced-by-count":3,"title":["Histomorfometria da microarquitetura \u00f3ssea em ratas tratadas com vitamina D e bisfosfonato no manejo da osteoporose"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-4192","authenticated-orcid":false,"given":"Jos\u00e9 Reginaldo Alves de","family":"Queiroz J\u00fanior","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias M\u00e9dicas, Universidade Federal de Pernambuco, Recife, PE, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-9181","authenticated-orcid":false,"given":"Marina Falc\u00e3o de 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Jeanine Martins de","family":"Lemos","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Departamento de Morfologia e Fisiologia Animal, Universidade Federal de Campina Grande, Campina Grande, PB, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-5018","authenticated-orcid":false,"given":"Carina Scanoni","family":"Maia","sequence":"additional","affiliation":[{"name":"Departamento de Histologia e Embriologia, Universidade Federal de Pernambuco, Recife, PE, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S452","DOI":"10.1016\/j.rbr.2017.06.001","article-title":"Diretrizes brasileiras para o diagn\u00f3stico e tratamento da osteoporose em mulheres na p\u00f3s-menopausa","volume":"57","author":"S C 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