{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:34:31Z","timestamp":1785267271477,"version":"3.55.0"},"reference-count":90,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"02","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To examine the possible effects of adrenal prohormones in the prediction of clinical and metabolic abnormalities in women with polycystic ovary syndrome (PCOS).<\/jats:p><jats:p>\n          Methods\u2003The present study enrolled 299 normal cycling non-PCOS, 156 normoandrogenemic, and 474 hyperandrogenemic women with PCOS. Baseline characteristics were compared using a chi-squared test or analysis of variance (ANOVA) as appropriate. The roles of adrenal prohormones and their ratios with total testosterone in predicting co-occurring morbidities in women PCOS were evaluated using univariate and multivariate logistic regression analyses.<\/jats:p><jats:p>\n          Results\u2003Adrenal hyperandrogenism per dehydroepiandrosterone sulfate (DHEAS) levels were found in 32% of women with PCOS. In non-PCOS women, dehydroepiandrosterone (DHEA) and its sulfate had no predictive role concerning clinical, anthropometric, and metabolic parameters. In PCOS women, mainly in the hyperandrogenemic group, DHEA showed to be a significant predictor against most anthropometric-metabolic index abnormalities (odds ratio [OR]\u2009=\u20090.36\u20130.97; p\u2009&lt;\u20090.05), and an increase in triglycerides (TG) levels (OR\u2009=\u20090.76; p\u2009=\u20090.006). Dehydroepiandrosterone sulfate presented a few predictive effects regarding PCOS-associated disorders. In controls, DHEAS predicted against the increase in estimated average glucose (OR= 0.38; p\u2009=\u20090.036). In the normoandrogenic group, it predicted against elevation in the waist\/hip ratio (WHR) (OR= 0.59; p\u2009=\u20090.042), and in hyperandrogenemic PCOS women, it predicted against abnormality in the conicity index (CI) (OR\u2009=\u20090.31; p\u2009=\u20090.028).<\/jats:p><jats:p>\n          Conclusion\u2003Dehydroepiandrosterone was shown to be a better predictor of abnormal anthropometric and biochemical parameters in women with PCOS than DHEAS. Thus, regarding adrenal prohormones, DHEA measurement, instead of DHEAS, should be preferred in PCOS management. The effects of androgen prohormones on the prediction of PCOS abnormalities are weak.<\/jats:p>","DOI":"10.1055\/s-0041-1741030","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T23:54:58Z","timestamp":1645833298000},"page":"142-153","source":"Crossref","is-referenced-by-count":5,"title":["Adrenal Androgen Predictive Effects on Clinical and Metabolic Abnormalities of Polycystic Ovary Syndrome"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-2515","authenticated-orcid":false,"given":"Sebasti\u00e3o Freitas de","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Medical School, Universidade Federal do Mato Grosso, Cuiab\u00e1, MT, Brazil"},{"name":"Instituto Tropical de Medicina Reprodutiva, Cuiab\u00e1, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-6766","authenticated-orcid":false,"given":"Bruna Barcelo","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Instituto Tropical de Medicina Reprodutiva, Cuiab\u00e1, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4069-7490","authenticated-orcid":false,"given":"Matheus Ant\u00f4nio Souto de","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Instituto Tropical de Medicina Reprodutiva, Cuiab\u00e1, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9231-3466","authenticated-orcid":false,"given":"Ana Karine Lin Winck","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Universidade de Cuiab\u00e1, Cuiab\u00e1, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-4226","authenticated-orcid":false,"given":"M\u00e1rcia Marly Winck","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Instituto Tropical de Medicina Reprodutiva, Cuiab\u00e1, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"W A March","year":"2010","journal-title":"Hum Reprod"},{"key":"ref2","first-page":"377","volume-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","author":"J K 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