{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:29:32Z","timestamp":1790818172171,"version":"4.1.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg J (N Y)"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Brunner's gland hamartomas (BGH) are rare benign lesions with an incidence of &lt;0.01%, accounting for 5 to 10% of all benign tumors of the duodenum. It requires expeditious management by a multidisciplinary team. The aim of the study is to report our experience with surgery for BGH.<\/jats:p><jats:p>\n          Methodology\u2003Data of all patients who underwent surgical intervention for duodenal polypoidal mass between August 2007 and March 2020 were retrieved from our prospectively maintained gastrointestinal (GI) surgery database. All patients whose histopathology report of the resected specimen confirmed BGH (n\u2009=\u20099) were included in the present study. Other pathological diagnosis like duodenal lipoma (n\u2009=\u20092), ganglioneuroma (n\u2009=\u20091), adenoma (n\u2009=\u200910), and adenocarcinoma (n\u2009=\u20094) were excluded.<\/jats:p><jats:p>\n          Results\u2003Nine patients had confirmatory histopathological diagnosis of BGH and met our inclusion criteria. Three (33.3%) of them were men with a median age of 45 (range: 24\u201361) years. The median interval between onset of symptoms and diagnosis of duodenal polyp was 14 (range: 4\u2013180) days. Five patients (55.5%) presented with upper GI hemorrhage. Three (33.3%) patients presented with abdominal pain, and one (11.1%) patient presented with episodes of bilious vomiting. Diagnostic endoscopy could detect the lesion in all (100%) patients. Contrast-enhanced computed tomography detected duodenal polypoidal lesion in five (55.5%) patients. The mean size of tumor was 4.78\u2009\u00b1\u20091.36\u2009cm. These lesions were symptomatic in all the patients and warranted intervention. In view of failed endoscopic intervention (n\u2009=\u20097, 77.7%), or extramural extension of the tumor (n\u2009=\u20092, 22.2%), surgical intervention was considered. Most commonly performed operation was duodenal polypectomy (n\u2009=\u20096, 66.6%). Three postoperative complications developed in two (22.2%) patients. There was no surgery-related mortality. After a median follow-up of 60 (12 -78) months, no patient developed GI bleed or intestinal obstruction.<\/jats:p><jats:p>\n          Conclusion\u2003In this study, the clinical profile of BGH was explored from the surgeon's point of view. Although endoscopic management is the first-line treatment, surgery plays an important role, particularly, if this fails or is not feasible. In experienced hand, surgery can be performed with acceptable perioperative morbidity and mortality and long-term satisfactory outcomes.<\/jats:p>","DOI":"10.1055\/s-0041-1741510","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T23:30:19Z","timestamp":1642462219000},"page":"e14-e18","source":"Crossref","is-referenced-by-count":8,"title":["Surgical Outcome of Brunner's Gland Hamartoma: A Single-Centre Experience"],"prefix":"10.1055","volume":"08","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-2569","authenticated-orcid":false,"given":"Arkadeep","family":"Dhali","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanta","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuhin S.","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somak","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranajoy","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Pathology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujan","family":"Khamrui","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal K.","family":"Dhali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avik","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Radiology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s12325-021-01750-6","article-title":"Brunner's gland hamartoma of the duodenum: a literature review","volume":"38","author":"M 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hamartomas: clinical presentation and pathological features of 27 cases","volume":"90","author":"J A Levine","year":"1995","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1055\/s-2000-9623","article-title":"Biliary obstruction and pancreatitis caused by Brunner's gland hyperplasia of the ampulla of Vater: a case report and review of the literature","volume":"32","author":"W Mayoral","year":"2000","journal-title":"Endoscopy"},{"issue":"04","key":"ref13","first-page":"246","article-title":"Hyperplasia of Brunner's glands of the duodenum","volume":"43","author":"J W Fuller","year":"1977","journal-title":"Am Surg"},{"issue":"06","key":"ref14","first-page":"519","article-title":"A case of Brunner's glands hyperplasia with diarrhea responsive to cimetidine","volume":"73","author":"M A Spellberg","year":"1980","journal-title":"Am J 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Krishnamurthy","year":"2006","journal-title":"Gastrointest Endosc"}],"container-title":["The Surgery 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