{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T15:59:16Z","timestamp":1706025556567},"reference-count":164,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastrointestinal bleeding (GIB) is serious, intractable, and potentially life-threatening condition. There is considerable heterogeneity in GIB phenotypes among congenital bleeding disorders (CBDs), making GIB difficult to manage. Although GIB is rarely encountered in CBDs, its severity in some patients makes the need for a comprehensive and precise assessment of underlying factors and management approaches imperative. Initial evaluation of GIB begins with assessment of hematological status; GIB should be ruled out in patients with chronic anemia, and in presentations that include hematemesis, hematochezia, or melena. High-risk patients with recurrent GIB require urgent interventions such as replacement therapy for treatment of coagulation factor deficiency (CFD). However, the best management strategy for CFD-related bleeding remains controversial. While several investigations have identified CBDs as potential risk factors for GIB, research has focused on assessing the risks for individual factor deficiencies and other CBDs. This review highlights recent findings on the prevalence, management strategies, and alternative therapies of GIB related to CFDs, and platelet disorders.<\/jats:p>","DOI":"10.1055\/s-0041-1741571","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T23:48:20Z","timestamp":1642031300000},"page":"529-541","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal Bleeding in Congenital Bleeding Disorders"],"prefix":"10.1055","volume":"48","author":[{"given":"Amir","family":"Samii","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahshaad","family":"Norouzi","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akbar","family":"Dorgalaleh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/hae.12571","article-title":"The natural history of occult or angiodysplastic gastrointestinal bleeding in von Willebrand disease","volume":"21","author":"M 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