{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:44:18Z","timestamp":1790451858427,"version":"4.1.0"},"reference-count":98,"publisher":"Georg Thieme Verlag KG","issue":"01\/02","funder":[{"name":"NIH\/NICHD","award":["NIH R01 HD102060"],"award-info":[{"award-number":["NIH R01 HD102060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperandrogenism\u2014clinical features resulting from increased androgen production and\/or action\u2014is not uncommon in peripubertal girls. Hyperandrogenism affects 3 to 20% of adolescent girls and often is associated with hyperandrogenemia. In prepubertal girls, the most common etiologies of androgen excess are premature adrenarche (60%) and congenital adrenal hyperplasia (CAH; 4%). In pubertal girls, polycystic ovary syndrome (PCOS; 20\u201340%) and CAH (14%) are the most common diagnoses related to androgen excess. Androgen-secreting ovarian or adrenal tumors are rare (0.2%). Early pubic hair, acne, and\/or hirsutism are the most common clinical manifestations, but signs of overt virilization in adolescent girls\u2014rapid progression of pubic hair or hirsutism, clitoromegaly, voice deepening, severe cystic acne, growth acceleration, increased muscle mass, and bone age advancement past height age\u2014should prompt detailed evaluation. This article addresses the clinical manifestations of and management considerations for non-PCOS-related hyperandrogenism in adolescent girls. We propose an algorithm to aid diagnostic evaluation of androgen excess in this specific patient population.<\/jats:p>","DOI":"10.1055\/s-0041-1742259","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T23:38:17Z","timestamp":1642721897000},"page":"042-052","source":"Crossref","is-referenced-by-count":18,"title":["Non-PCOS Hyperandrogenic Disorders in Adolescents"],"prefix":"10.1055","volume":"40","author":[{"given":"M. Rebeca","family":"Esquivel-Zuniga","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra K.","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-4982","authenticated-orcid":false,"given":"Christopher R.","family":"McCartney","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia"},{"name":"Center for Research in Reproduction, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-2995","authenticated-orcid":false,"given":"Christine M.","family":"Burt Solorzano","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia"},{"name":"Center for Research in Reproduction, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/humrep\/der102","article-title":"Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis","volume":"26","author":"M Hickey","year":"2011","journal-title":"Hum 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