{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:15:15Z","timestamp":1787879715971,"version":"build-2784847793"},"reference-count":37,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"University Grants Commission-National Fellowship for Higher Education"},{"name":"Sri Balaji Aarogya Vara Prasadini Scheme of Sri Venkateswara Institute of Medical Sciences, Tirupati"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Type 2 diabetes mellitus (T2DM) associated with oxidative stress and inflammation causes endothelial dysfunction, which promotes cardiovascular risk. Vitamin D with its pleiotropic effect is said to protect against cardiovascular risk. However, with vitamin D deficiency being more prevalent in T2DM, the cardiovascular risk may get compounded.<\/jats:p><jats:p>\n          Materials and Methods\u2003An interventional study was conducted on 100 patients with T2DM having vitamin D deficiency (vitamin D\u2009&lt;\u200920\u2009ng\/mL), who were given oral supplementation of 2,000\u2009IU\/day of vitamin D for a period of 6 months. Serum vitamin D, biomarkers of oxidative stress, malondialdehyde (MDA), oxidized LDL (OxLDL), ferric reducing ability of plasma (FRAP), biomarkers of inflammation, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), and fibrinogen were measured at baseline and at the end of the third and sixth month of vitamin D supplementation.<\/jats:p><jats:p>\n          Statistical Analysis\u2003Repeated measures analysis of variance (ANOVA) was applied for comparison between baseline and third- and sixth-month data after vitamin D supplementation. Linear regression by generalized estimating equations (GEE), which grouped repeated measures for each subject and accounted for correlations that may occur from multiple observations within subjects, was applied.<\/jats:p><jats:p>\n          Results\u2003Serum vitamin D levels reached normal levels with a significant decrease in OxLDL, hsCRP, IL-6, PAI-1, and fibrinogen levels, with a significant increase in FRAP (p\u2009=\u20090.001) levels at the end of 6 months of vitamin D supplementation. These changes were observed even after correction with glycemic control (HbA1c). However, a significant decrease in MDA was observed only at the end of the sixth month of vitamin D supplementation. Vitamin D levels showed a significant negative association with Ox-LDL, Hs-CRP, IL-6, PAI-1, and fibrinogen, even after adjusting for BMI and statin use (p\u2009=\u20090.001).<\/jats:p><jats:p>\n          Conclusion\u2003Supplementation of vitamin D for a period of 6 months in patients with T2DM having vitamin D deficiency is beneficial in the attenuation of oxidative stress and inflammation.<\/jats:p>","DOI":"10.1055\/s-0041-1742285","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:07:10Z","timestamp":1640995630000},"page":"190-196","source":"Crossref","is-referenced-by-count":6,"title":["Attenuation of Oxidative Stress, Interleukin-6, High-Sensitivity C-Reactive Protein, Plasminogen Activator Inhibitor-1, and Fibrinogen with Oral Vitamin D Supplementation in Patients with T2DM having Vitamin D Deficiency"],"prefix":"10.25259","volume":"14","author":[{"given":"Pullaiah","family":"Pasupuleti","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Suchitra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna R.","family":"Bitla","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Sachan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, 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