{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T19:28:32Z","timestamp":1648841312202},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An\u00e4sthesiol Intensivmed Notfallmed Schmerzther"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Der massive intraoperative Blutverlust stellt eine potenziell lebensbedrohliche Komplikation w\u00e4hrend eines operativen Eingriffs dar. Die letale Trias aus schockbedingter Azidose, Hypothermie und Koagulopathie verst\u00e4rkt die Blutungsneigung zus\u00e4tzlich. Um diesen circulus vitiosus zu vermeiden, erfordert das Management einer intraoperativen Massivblutung ein strukturiertes und standardisiertes Vorgehen. Vorrangige Behandlungsziele sind dabei die Aufrechterhaltung einer ad\u00e4quaten Gewebeoxygenierung, die Wiederherstellung einer suffizienten Gerinnungsfunktion, sowie Normothermie und die Hom\u00f6ostase des S\u00e4ure-Basen- und Elektrolythaushaltes. Der vorliegende Artikel veranschaulicht diese Therapieziele und ihre pathophysiologischen Hintergr\u00fcnde anhand eines Fallbeispiels.<\/jats:p>","DOI":"10.1055\/s-0042-102821","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T22:34:21Z","timestamp":1493850861000},"page":"288-296","source":"Crossref","is-referenced-by-count":1,"title":["Management des massiven intraoperativen Blutverlusts anhand eines Fallbeispiels"],"prefix":"10.1055","volume":"52","author":[{"given":"Andreas","family":"Pape","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Warszawska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian J.","family":"Raimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zacharowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/bja\/85.3.487","article-title":"Management of massive blood loss: a template guideline","volume":"85","author":"D Stainsby","year":"2000","journal-title":"Br J Anaesth"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00101-012-2136-8","article-title":"Umgang mit Massivblutungen und assoziierten perioperativen Gerinnungsst\u00f6rungen","volume":"62","author":"O Grottke","year":"2013","journal-title":"Anaesthesist"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/EJA.0b013e32835f4d5b","article-title":"Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology","volume":"30","author":"S A Kozek-Langenecker","year":"2013","journal-title":"Eur J Anaesthesiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"R76","DOI":"10.1186\/cc12685","article-title":"Management of bleeding and coagulopathy following major trauma: an updated European guideline","volume":"17","author":"D R Spahn","year":"2013","journal-title":"Crit Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1007\/s00101-006-1055-y","article-title":"Perioperative An\u00e4mietoleranz. 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