{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:17:12Z","timestamp":1776820632420,"version":"3.51.2"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall in Med"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002To establish the performance of a multi-parametric test including maternal risk factors and maternal uterine and ophthalmic artery Doppler in the second trimester of pregnancy for the prediction of preeclampsia (PE).<\/jats:p><jats:p>\n          Materials and Methods\u2002We performed a prospective observational cohort study with pregnant women who underwent a second trimester morphology scan. Maternal uterine and ophthalmic artery Doppler examinations were performed in 415 singleton pregnancies between 18 and 23 weeks of gestation. Additional history was obtained through participant questionnaires, and follow-up occurred to the time of discharge post-delivery. The control and PE groups were compared to continuous variables using the Kruskal-Wallis test and to categorical variables using the Chi-square and Fisher exact tests. Univariate and multivariate logistic regression analyses were performed to determine the best model for the prediction of PE.<\/jats:p><jats:p>\n          Results\u200240 (9.6\u200a%) pregnant women developed PE. We observed significant differences in the body mass index (BMI) (p\u200a&lt;\u200a0.001), parity (p\u200a&lt;\u200a0.001), mean arterial pressure (MAP) (p\u200a&lt;\u200a0.001), and pulsatility index (PI) of uterine artery Doppler (p\u200a&lt;\u200a0.001) between PE and control groups. The best model for the prediction of PE included maternal characteristics, MAP, maternal uterine and ophthalmic artery Doppler with area under receiver operating characteristics (ROC) curve of 0.710 (95\u200a% confidence interval, 613\u200a\u2013\u200a0.807) with a sensitivity of 45\u200a% to a false-positive rate of 10\u200a% and 35\u200a% to a false-positive rate of 5\u200a%.<\/jats:p><jats:p>\n          Conclusion\u2002Maternal ophthalmic artery Doppler did not promote a significant increase in the PE detection rate during the second trimester scan.<\/jats:p>","DOI":"10.1055\/s-0042-104649","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T12:32:47Z","timestamp":1465993967000},"page":"190-197","source":"Crossref","is-referenced-by-count":22,"title":["Second Trimester Screening of Preeclampsia Using Maternal Characteristics and Uterine and Ophthalmic Artery Doppler"],"prefix":"10.1055","volume":"39","author":[{"given":"Paulo","family":"Praciano de Souza","sequence":"additional","affiliation":[{"name":"Public Health, State University of Cear\u00e1 (UECE), Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio","family":"Gurgel Alves","sequence":"additional","affiliation":[{"name":"Public Health, State University of Cear\u00e1 (UECE), Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammya","family":"Bezerra Maia e Holanda Moura","sequence":"additional","affiliation":[{"name":"Public Health, State University of Cear\u00e1 (UECE), Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Obstetrics, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o\u00a0Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wellington","family":"Martins","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics, Ribeir\u00e3o Preto School of Medicine, University of S\u00e3o Paulo (DGO-FMRP-USP), Ribeir\u00e3o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Da Silva Costa","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2016,6,14]]},"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-104649.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T22:43:19Z","timestamp":1522968199000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-104649"}},"subtitle":["Prediction of Preeclampsia and Maternal Ophthalmic Artery Doppler"],"short-title":[],"issued":{"date-parts":[[2016,6,14]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2018,4,5]]},"published-print":{"date-parts":[[2018,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-104649","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,14]]}}}