{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:41:49Z","timestamp":1792179709243,"version":"4.4.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall in Med"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002To assess the spectrum of associated anomalies, the intrauterine course, the outcome and possible prognostic markers in prenatally diagnosed Ebstein\u2019s anomaly (EA).<\/jats:p><jats:p>\n          Materials and Methods\u2002All cases of EA diagnosed over a period of 13 years with a minimum follow-up of 1 year were retrospectively collected in 4\u00a0tertiary referral centers in Germany.<\/jats:p><jats:p>\n          Results\u2002In the study period 76 cases of EA were prenatally diagnosed. The mean gestational age at\u00a0diagnosis was 25.0\u00a0weeks (range: 13\u200a\u2013\u200a35). 41\u00a0(53.9\u200a%) cases were isolated and 35 (46.1\u200a%) had other cardiac and\/or extracardiac anomalies. 19 (25.0\u200a%) pregnant women opted for termination of pregnancy, intrauterine fetal death occurred in 7\u00a0cases (9.2\u200a%), neonatal death in 14 cases (18.4\u200a%), death in infancy or childhood in 9 cases (11.8\u200a%) and 27 children (35.5\u200a%) were alive at the last follow-up.\u200aAfter exclusion of terminations, the only parameter inversely correlated with intrauterine survival was hydrops fetalis. Prognostic parameters significantly associated with postnatal non-survival were an abnormal Celermajer index (right atrium\/heart ratio &gt;\u200a0.7), cardiomegaly (cardiothoracic circumference ratio &gt;\u200a0.5), absence of antegrade flow over the pulmonary valve and earlier diagnosis in pregnancy.<\/jats:p><jats:p>\n          Conclusion\u2002Prenatally diagnosed EA has a high morbidity and mortality with the highest loss rate in the intrauterine and neonatal period. In our study, hydrops fetalis was the only parameter significantly associated with intrauterine demise, while other prenatal markers were only significantly associated with postnatal mortality.<\/jats:p>","DOI":"10.1055\/s-0042-107151","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T02:30:50Z","timestamp":1464834650000},"page":"427-436","source":"Crossref","is-referenced-by-count":11,"title":["Ebstein\u2019s Anomaly of the Tricuspid Valve in the Fetus \u2013 A\u00a0Multicenter Experience"],"prefix":"10.1055","volume":"38","author":[{"given":"Ingo","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine and Gynecologic Sonography, Department of Obstetrics and Gynecology, University of K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine and Gynecologic Sonography, Department of Obstetrics and Gynecology, University of K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Stressig","sequence":"additional","affiliation":[{"name":"praenatal.de K\u00f6ln, Prenatal Medicine and Genetics, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Ritgen","sequence":"additional","affiliation":[{"name":"praenatal.de K\u00f6ln, Prenatal Medicine and Genetics, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Herberg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Oberhoffer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Centre Munich, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Willruth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine and Gynecologic Sonography, Department of Obstetrics and Gynecology, University of K\u00f6ln, Germany"},{"name":"Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2016,6,1]]},"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-107151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T09:34:12Z","timestamp":1513676052000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-107151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,8,3]]},"published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-107151","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,1]]}}}