{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T17:27:37Z","timestamp":1649006857323},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall in Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002Inhomogeneity of arterial wall thickness may be indicative of distal plaques. This study investigates the intra-subject association between relative spatial intima-media thickness (IMT) inhomogeneity of the common carotid artery (CCA) and the degree of stenosis of plaques in the internal carotid artery (ICA).<\/jats:p><jats:p>\n          Materials and Methods\u2002We included 240 patients with a recent ischemic stroke or transient ischemic attack and mild-to-moderate stenosis in the ipsilateral ICA. IMT inhomogeneity was extracted from B-mode ultrasound recordings. The\u00a0degree of ICA stenosis was assessed on CT angiography according to the European Carotid Surgery Trial method. Patients were divided into groups with a low (\u2264\u200a2\u200a%) and a high (&gt;\u200a2\u200a%) IMT inhomogeneity scaled with respect to the local end-diastolic diameter.<\/jats:p><jats:p>\n          Results\u2002182 patients had suitable CT and ultrasound measurements. Relative CCA-IMT inhomogeneity was similar for the symptomatic and asymptomatic side (difference: 0.02\u200a%, p\u200a=\u200a0.85). High relative IMT inhomogeneity was associated with a larger IMT (difference: 235\u200a\u00b5m, p\u200a&lt;\u200a0.001) and larger degree of ICA stenosis (difference: 5\u200a%, p\u200a=\u200a0.023) which remained significant (p\u200a=\u200a0.016) after adjustment for common risk factors.<\/jats:p><jats:p>\n          Conclusion\u2002Regardless of common risk factors, high relative CCA-IMT inhomogeneity is associated with a greater degree of ICA stenosis and is\u00a0therefore indicative of atherosclerotic disease. The predictive value of CCA-IMT inhomogeneity for plaque progression and recurrence of cerebrovascular symptoms will be determined in the follow-up phase of PARISK.<\/jats:p>","DOI":"10.1055\/s-0042-112220","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T18:56:43Z","timestamp":1470250603000},"page":"523-529","source":"Crossref","is-referenced-by-count":2,"title":["High Spatial Inhomogeneity in the Intima-Media Thickness of the Common Carotid Artery is Associated with a Larger Degree of Stenosis in the Internal Carotid Artery: The\u00a0PARISK Study"],"prefix":"10.1055","volume":"38","author":[{"given":"Jeire","family":"Steinbuch","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, Maastricht University CARIM School for Cardiovascular Diseases, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Radiology, Erasmus MC, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floris","family":"Schreuder","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Truijman","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"de Rotte","sequence":"additional","affiliation":[{"name":"Radiology, University Medical Center Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Nederkoorn","sequence":"additional","affiliation":[{"name":"Neurology, Academic Medical Center Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aad","family":"van der Lugt","sequence":"additional","affiliation":[{"name":"Radiology, Erasmus MC, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelien","family":"Hermeling","sequence":"additional","affiliation":[{"name":"Radiology, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Hoeks","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, Maastricht University CARIM School for Cardiovascular Diseases, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Mess","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2016,8,3]]},"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-112220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T07:33:02Z","timestamp":1513668782000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-112220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2017,9,25]]},"published-print":{"date-parts":[[2017,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-112220","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}