{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:02:57Z","timestamp":1780563777666,"version":"3.54.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blockade of the angiotensin-renin system, with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), has been shown to improve cardiac outcomes following myocardial infarction and delay progression of heart failure. Acromegaly is associated with a disease-specific cardiomyopathy, the pathogenesis of which is poorly understood.<\/jats:p><jats:p>The cardiac indices of patients with active acromegaly with no hypertension (Group A, n=4), established hypertension not taking ACEi\/ARBs (Group B, n=4) and established hypertension taking ACEi\/ARBs (Group C, n=4) were compared using cardiac magnetic imaging.<\/jats:p><jats:p>Patients taking ACEi\/ARBs had lower end diastolic volume index (EDVi) and end systolic volume index (ESVi) than the other 2 groups ([C] 73.24 vs. [A] 97.92 vs. [B] 101.03\u2009ml\/m2, ANOVA p=0.034, B vs. C p&lt;0.01). Groups A and B had EDVi and ESVi values at the top of published reference range values; Group C had values in the middle of the range.<\/jats:p><jats:p>Acromegaly patients on ACEi\/ARBs for hypertension demonstrate improved cardiac indices compared to acromegaly patients with hypertension not taking these medications. Further studies are needed to determine if these drugs have a beneficial cardiac effect in acromegaly in the absence of demonstrable hypertension.<\/jats:p>","DOI":"10.1055\/s-0042-123710","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T23:39:37Z","timestamp":1486424377000},"page":"365-367","source":"Crossref","is-referenced-by-count":8,"title":["Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients"],"prefix":"10.1055","volume":"125","author":[{"given":"Julia","family":"Thomas","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, WHRI, Barts & the London School of Medicine and Dentistry, Queen Mary University of London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Dattani","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, WHRI, Barts & the London School of Medicine and Dentistry, Queen Mary University of London"},{"name":"NIHR Cardiovascular Biomedical Research Unit, St Bartholomew\u2019s Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Zemrak","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, St Bartholomew\u2019s Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Burchell","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, St Bartholomew\u2019s Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Akker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew\u2019s Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Lister Hospital, Stevenage, Herts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal Free Campus, UCL Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Aylwin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, King\u2019s College Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Grossman","sequence":"additional","affiliation":[{"name":"Oxford Centre for Endocrinology, Diabetes and Metabolism, University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Davies","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, St Bartholomew\u2019s Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Korbonits","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, WHRI, Barts & the London School of Medicine and Dentistry, Queen Mary University of London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,2,6]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-123710.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T07:19:49Z","timestamp":1513667989000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-123710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2017,6,20]]},"published-print":{"date-parts":[[2017,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-123710","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}