{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:30:09Z","timestamp":1793115009712,"version":"4.5.0"},"reference-count":69,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"06","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (SCD) is the most common monogenic disease worldwide, with a variable prevalence in each continent. A single nucleotide substitution leads to an amino-acid change in the \u03b2-globin chain, altering the normal structure ofhemoglobin, which is then called hemoglobin S inherited in homozygosity (HbSS) or double heterozygosity (HbSC, HbS\u03b2), and leads to chronic hemolysis, vaso-occlusion, inflammation, and endothelium activation. Pregnant women with SCD are at a higher risk of developing maternal and perinatal complications. We performed a narrative review of the literature considering SCD and pregnancy, the main clinical and obstetrical complications, the specific antenatal care, and the follow-up for maternal and fetal surveillance. Pregnant women with SCD are at a higher risk of developing clinical and obstetric complications such as pain episodes, pulmonary complications, infections, thromboembolic events, preeclampsia, and maternal death. Their newborns are also at an increased risk of developing neonatal complications: fetal growth restriction, preterm birth, stillbirth. Severe complications can occur in patients of any genotype. We concluded that SCD is a high-risk condition that increases maternal and perinatal morbidity and mortality. A multidisciplinary approach during pregnancy and the postpartum period is key to adequately diagnose and treat complications.<\/jats:p>","DOI":"10.1055\/s-0042-1742314","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T23:53:28Z","timestamp":1644450808000},"page":"593-601","source":"Crossref","is-referenced-by-count":14,"title":["Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-8094","authenticated-orcid":false,"given":"Camilla Olivares","family":"Figueira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4335-0337","authenticated-orcid":false,"given":"Fernanda Garanhani","family":"Surita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-3297","authenticated-orcid":false,"given":"Kleber","family":"Fertrin","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-4256","authenticated-orcid":false,"given":"Guilherme de Moraes","family":"Nobrega","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-3234","authenticated-orcid":false,"given":"Maria Laura","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1365-2141.2001.02557.x","article-title":"The emerging understanding of sickle cell disease","volume":"112","author":"G R Serjeant","year":"2001","journal-title":"Br J Haematol"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bpobgyn.2011.10.001","article-title":"The obstetric management of sickle cell disease","volume":"26","author":"J Howard","year":"2012","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/S0140-6736(12)61229-X","article-title":"Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates","volume":"381","author":"F B Piel","year":"2013","journal-title":"Lancet"},{"issue":"03","key":"ref4","first-page":"375","article-title":"Prevention and control of haemoglobinopathies","volume":"73","author":"M Angastiniotis","year":"1995","journal-title":"Bull World Health Organ"},{"issue":"10","key":"ref5","doi-asserted-by":"publisher","first-page":"CD011175","DOI":"10.1002\/14651858.CD011175.pub2","article-title":"Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related complications","volume":"10","author":"M R Asnani","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"ref6","first-page":"S2531","article-title":"Sickle cell disease related mortality in Brazil, 2000-2018","volume":"\u2022\u2022\u2022","author":"A H Santo","year":"2020","journal-title":"Hematol Transfus Cell Ther"},{"issue":"01","key":"ref7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/ijns5010011","article-title":"The Neonatal Screening Program in Brazil, Focus on Sickle Cell Disease (SCD)","volume":"5","author":"A C Silva-Pinto","year":"2019","journal-title":"Int J Neonatal Screen"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0140-6736(17)30193-9","article-title":"Sickle cell disease","volume":"390","author":"R E Ware","year":"2017","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1136\/bmj.314.7079.492","article-title":"ABC of clinical haematology. 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