{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:22:22Z","timestamp":1793949742221,"version":"4.8.0"},"reference-count":26,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"04","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The presence of an extensive intraductal component is associated to an increasing risk of relapse in the nipple-areola complex. The aim of the present study was to evaluate the outcomes of patients diagnosed with ductal carcinoma in situ (DCIS) who underwent nipple-sparing mastectomy (NSM) with immediate breast reconstruction using silicone implants.<\/jats:p><jats:p>\n          Methods\u2003We retrospectively analyzed the postoperative complications and oncological safety of 67 breast cancer patients diagnosed with pure DCIS who underwent NSM with immediate breast reconstruction using silicone implants between 2004 and 2018.<\/jats:p><jats:p>\n          Results\u2003Among the 127 NSM procedures performed, 2 hematomas (1.5%) and 1 partial nipple necrosis (0.7%) were observed. After a mean follow-up of 60 months, the local recurrence rate was of 8.9%, the disease-free survival rate was of 90%, and 1 of the patients died.<\/jats:p><jats:p>\n          Conclusion\u2003Despite the local recurrence rate, we showed that NSM with immediate breast reconstruction using silicone implants is a feasible surgical approach, with a low rate of complications and high survival rates for patients with a diagnosis of pure DCIS when breast-conserving surgery is not an option.<\/jats:p>","DOI":"10.1055\/s-0042-1742315","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T23:24:17Z","timestamp":1653693857000},"page":"376-384","source":"Crossref","is-referenced-by-count":3,"title":["Nipple-sparing Mastectomy with Immediate Implant-based Reconstruction for Patients with Pure Ductal Carcinoma in Situ"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-6898","authenticated-orcid":false,"given":"Ant\u00f4nio Luiz","family":"Frasson","sequence":"additional","affiliation":[{"name":"Mastology Service, Hospital S\u00e3o Lucas, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-9390","authenticated-orcid":false,"given":"Ana Beatriz","family":"Falcone","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"},{"name":"Mastology Service, Hospital S\u00e3o Lucas, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9878-8996","authenticated-orcid":false,"given":"Isabela","family":"Miranda","sequence":"additional","affiliation":[{"name":"Mastology Service, Hospital S\u00e3o Lucas, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-7076","authenticated-orcid":false,"given":"Alessandra Borba Anton de","family":"Souza","sequence":"additional","affiliation":[{"name":"Mastology Service, Hospital S\u00e3o Lucas, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-6029","authenticated-orcid":false,"given":"Betina","family":"Vollbrecht","sequence":"additional","affiliation":[{"name":"Mastology Service, Hospital S\u00e3o Lucas, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-1993","authenticated-orcid":false,"given":"Fernanda","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-147X","authenticated-orcid":false,"given":"M\u00f4nica Adriana Rodriguez Martinez","family":"Frasson","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-4646","authenticated-orcid":false,"given":"Martina","family":"Lichtenfels","sequence":"additional","affiliation":[{"name":"Mastology Service, Hospital S\u00e3o Lucas, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1093\/annonc\/mdr566","article-title":"Risk factors associated with recurrence after nipple-sparing mastectomy for invasive and intraepithelial neoplasia","volume":"23","author":"J Y Petit","year":"2012","journal-title":"Ann Oncol"},{"issue":"10","key":"ref2","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1245\/s10434-015-4739-1","article-title":"Overall survival, disease-free survival, local recurrence, and nipple-areolar recurrence in the setting of nipple-sparing mastectomy: a meta-analysis and systematic review","volume":"22","author":"L De La Cruz","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.breast.2015.10.010","article-title":"Nipple sparing mastectomy: Surgical and oncological outcomes from a national multicentric registry with 913 patients (1006 cases) over a six year period","volume":"25","author":"L Orzalesi","year":"2016","journal-title":"Breast"},{"issue":"03","key":"ref4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jamcollsurg.2017.06.013","article-title":"Oncologic safety of nipple-sparing mastectomy in women with breast cancer","volume":"225","author":"B L Smith","year":"2017","journal-title":"J Am Coll Surg"},{"issue":"10","key":"ref5","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1245\/s10434-016-5370-5","article-title":"Nipple-sparing mastectomy: indications, contraindications, risks, benefits, and techniques","volume":"23","author":"T J Hieken","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"S 01","key":"ref6","doi-asserted-by":"publisher","first-page":"S82","DOI":"10.1016\/j.breast.2017.06.034","article-title":"Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindications","volume":"34","author":"V Galimberti","year":"2017","journal-title":"Breast"},{"issue":"03","key":"ref7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.clbc.2017.08.010","article-title":"Expanding the criteria for nipple-sparing mastectomy in patients with poor prognostic features","volume":"18","author":"P Jadeja","year":"2018","journal-title":"Clin Breast Cancer"},{"issue":"11","key":"ref8","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1001\/jamasurg.2019.2959","article-title":"Breast cancer recurrence in the nipple-areola complex after nipple-sparing mastectomy with immediate breast reconstruction","volume":"154","author":"Z Y Wu","year":"2019","journal-title":"JAMA Surg"},{"issue":"01","key":"ref9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3978\/j.issn.2227-684X.2015.10.02","article-title":"Conservative mastectomies for breast cancer and risk-reducing surgery: the Memorial Sloan Kettering Cancer Center experience","volume":"5","author":"A T Manning","year":"2016","journal-title":"Gland Surg"},{"issue":"02","key":"ref10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s00266-013-0236-8","article-title":"Nipple-sparing mastectomy and immediate reconstruction in ductal carcinoma in situ: a critical assessment with 41 patients","volume":"38","author":"F M Lecl\u00e8re","year":"2014","journal-title":"Aesthetic Plast Surg"},{"issue":"03","key":"ref11","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/tbj.12947","article-title":"Nipple-sparing mastectomy as treatment for patients with ductal carcinoma in situ: A 10-year follow-up study","volume":"24","author":"V Lago","year":"2018","journal-title":"Breast J"},{"issue":"05","key":"ref12","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1245\/s10434-019-08184-z","article-title":"Recurrence outcomes after nipple-sparing mastectomy and immediate breast reconstruction in patients with pure ductal carcinoma in situ","volume":"27","author":"Z Y Wu","year":"2020","journal-title":"Ann Surg Oncol"},{"issue":"13","key":"ref13","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.1245\/s10434-018-6759-0","article-title":"Oncological outcomes of nipplesparing mastectomy: a single-center experience of 1989 patients","volume":"25","author":"V Galimberti","year":"2018","journal-title":"Ann Surg Oncol"},{"issue":"02","key":"ref14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s12282-014-0570-y","article-title":"Short-term outcomes of immediate breast reconstruction using an implant or tissue expander after mastectomy in breast cancer patients","volume":"23","author":"S W Kim","year":"2016","journal-title":"Breast Cancer"},{"issue":"03","key":"ref15","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s12282-016-0726-z","article-title":"Current trends and outcomes of breast reconstruction following nipple-sparing mastectomy: results from a national multicentric registry with 1006 cases over a 6-year period","volume":"24","author":"D Casella","year":"2017","journal-title":"Breast Cancer"},{"issue":"04","key":"ref16","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/jso.24364","article-title":"Patient satisfaction with nipple-sparing mastectomy: A prospective study of patient reported outcomes using the BREAST-Q","volume":"114","author":"M A Howard","year":"2016","journal-title":"J Surg Oncol"},{"issue":"02","key":"ref17","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/PRS.0000000000003505","article-title":"Quality-of-life outcomes improve with nipple-sparing mastectomy and breast reconstruction","volume":"140","author":"C R Bailey","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"06","key":"ref18","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s12282-015-0651-6","article-title":"Oncologic outcomes and technical considerations of nipple-sparing mastectomies in breast cancer: experience of 425 cases from a single institution","volume":"23","author":"A Shimo","year":"2016","journal-title":"Breast Cancer"},{"issue":"04","key":"ref19","doi-asserted-by":"publisher","first-page":"328","DOI":"10.5999\/aps.2016.43.4.328","article-title":"The oncological safety of nipple-sparing mastectomy: a systematic review of the literature with a pooled analysis of 12,358 procedures","volume":"43","author":"H L Headon","year":"2016","journal-title":"Arch Plast Surg"},{"issue":"05","key":"ref20","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1159\/000489317","article-title":"Nipple-sparing mastectomy with primary implant reconstruction: surgical and oncological outcome of 435 breast cancer patients","volume":"13","author":"Z Radovanovic","year":"2018","journal-title":"Breast Care (Basel)"},{"issue":"11","key":"ref21","doi-asserted-by":"publisher","first-page":"CD000563","DOI":"10.1002\/14651858.CD000563.pub7","article-title":"Post-operative radiotherapy for ductal carcinoma in situ of the breast","author":"A Goodwin","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"06","key":"ref22","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/jnci\/djr027","article-title":"Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS","volume":"103","author":"I L Wapnir","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"05","key":"ref23","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1093\/annonc\/mdv062","article-title":"Molecular phenotypes of DCIS predict overall and invasive recurrence","volume":"26","author":"K E Williams","year":"2015","journal-title":"Ann Oncol"},{"issue":"06","key":"ref24","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/bjc.2012.41","article-title":"HER2\/neu and Ki-67 expression predict non-invasive recurrence following breast-conserving therapy for ductal carcinoma in situ","volume":"106","author":"E Rakovitch","year":"2012","journal-title":"Br J Cancer"},{"issue":"01","key":"ref25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/CEJ.0000000000000131","article-title":"Predictors for local invasive recurrence of ductal carcinoma in situ of the breast: a meta-analysis","volume":"25","author":"X Zhang","year":"2016","journal-title":"Eur J Cancer Prev"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.breast.2015.10.007","article-title":"Hormonal receptor status, Ki-67 and HER2 expression: Prognostic value in the recurrence of ductal carcinoma in situ of the breast?","volume":"25","author":"N Poulakaki","year":"2016","journal-title":"Breast"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/nipple-sparing-mastectomy-with-immediate-implant-based-reconstruction-for-patients-with-pure-ductal-carcinoma-in-situ\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1742315.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:55:01Z","timestamp":1721336101000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/nipple-sparing-mastectomy-with-immediate-implant-based-reconstruction-for-patients-with-pure-ductal-carcinoma-in-situ\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":26,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,5,27]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1742315","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}