{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T08:48:04Z","timestamp":1766911684406,"version":"3.37.3"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rotavirus infection has been reported to be associated with neonatal seizures with a diffuse and symmetrical diffusion restriction of periventricular white matter, namely, neonatal rotavirus-associated leukoencephalopathy. The extensive white matter injury seen in this cohort raises concerns about the long-term neurodevelopmental outcomes. In the present study, we prospectively assessed the neurodevelopmental outcomes of 13 patients with neonatal rotavirus-associated leukoencephalopathy at a median age of 26 months (range, 23\u201368 months). Neurodevelopmental outcomes were evaluated using a neurological examination, developmental evaluations, and magnetic resonance imaging (MRI) of the brain. Overall, 6 of the 13 patients (46%) had abnormal neurodevelopmental outcomes: 1 patient had mental retardation, visual\u2013motor integration (VMI) dysfunction, cerebral palsy, and epilepsy; 1 patient had cerebral palsy and VMI dysfunction; remaining 4 patients had VMI dysfunction. Follow-up MRI in 12 of 13 patients showed an increased signal intensity on periventricular white matter in all patients. These findings suggested that neonatal rotavirus-associated leukoencephalopathy could not be assumed to be benign in long-term neurodevelopment, particularly in VMI function. Early intervention and long-term follow-up are necessary for these patients. Our findings raise caution for rotavirus infection in this vulnerable population for infants.<\/jats:p>","DOI":"10.1055\/s-0042-1742722","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:29:30Z","timestamp":1646267370000},"page":"291-294","source":"Crossref","is-referenced-by-count":3,"title":["Neurodevelopmental Outcomes of Neonatal Rotavirus-Associated Leukoencephalopathy"],"prefix":"10.1055","volume":"53","author":[{"given":"Jae Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0688-7493","authenticated-orcid":false,"given":"Jung Sook","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju, South Korea"},{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gyeongsang National University Hospital, Jinju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Seob","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"},{"name":"Department of Radiology, Gyeongsang National University Hospital, Jinju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju, South Korea"},{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sil","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju, South Korea"},{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju, South Korea"},{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju, South Korea"},{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang-Ok","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju, South Korea"},{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan-Hoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University Changwon Hospital, Changwon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1212\/WNL.0000000000001107","article-title":"Distinctive pattern of white matter injury in neonates with rotavirus infection","volume":"84","author":"J S Yeom","year":"2015","journal-title":"Neurology"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1177\/0883073814568153","article-title":"Association of rotavirus with seizures accompanied by cerebral white matter injury in neonates","volume":"30","author":"K W Oh","year":"2015","journal-title":"J Child Neurol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1177\/0883073820975275","article-title":"Neonatal rotavirus-associated leukoencephalopathy is one of the main causes of fifth-day fits","volume":"36","author":"K W 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