{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:22:36Z","timestamp":1776349356674,"version":"3.51.2"},"reference-count":14,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"04","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To evaluate the role of cervical cytology (Pap smear) in the diagnosis of cervical intraepithelial neoplasia 2 or greater (CIN2\u2009+\u2009), presented exclusively in the endocervical canal, the clinical-epidemiological characteristics of this lesion, the necessary length of canal to be removed to treat, and the rate of invasive lesion hidden in the endocervical canal.<\/jats:p><jats:p>\n          Methods\u2003Cross-sectional study, by database analysis, of patients with abnormal cytology (high-grade squamous intraepithelial lesion [HSIL]), without visible colposcopy lesion, submitted to loop electrosurgical procedure (LEEP) to evaluate the association of cytology results with the histological product of the conization, to identify the epidemiological characteristics of endocervical lesion and clinical evolution, using a p-value\u2009&lt;\u20090.05 and 95% CI.<\/jats:p><jats:p>\n          Results\u2003In 444 cases, the Pap smear sensitivity for CIN2+ diagnosis was 75% (95% CI: 69.8\u201379.7), specificity was 40% (95% CI: 30.2\u201349.5), and the prevalence rate of histological lesion was 73% (95% CI: 70.1\u201378.7). There was a higher prevalence of CIN2+ in women over 42 years old and invasive cancer in those over 56 years old (p\u2009&lt;\u20090.001), and it was necessary to remove 2.6\u2009cm in length of the canal to reduce the chance of recurrence (p\u2009&lt;\u20090.006). The rate of invasive cancer was 2.7%.<\/jats:p><jats:p>\n          Conclusion\u2003Cytology was related to a high prevalence to histological lesion (73%) in the diagnosis of CIN2+ in the endocervical disease; older patients presented a higher relationship with histological lesions in the canal disease, and it was necessary to remove an average of 2.6\u2009cm in length of the endocervical canal to avoid the persistence and progression of CIN. The rate of occult neoplasia in the endocervical canal was 2.7%.<\/jats:p>","DOI":"10.1055\/s-0042-1743102","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T23:39:52Z","timestamp":1647041992000},"page":"385-390","source":"Crossref","is-referenced-by-count":5,"title":["Cervical Intraepithelial Neoplasia: Analyzing the Disease Present Exclusively in the Endocervical Canal"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-9893","authenticated-orcid":false,"given":"Fernanda Villar","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Universidade Positivo, Curitiba, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9695-050X","authenticated-orcid":false,"given":"Maria Vict\u00f3ria Gutierrez","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Universidade Positivo, Curitiba, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-3609","authenticated-orcid":false,"given":"Ariadne Cristine","family":"Pozza","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Universidade Positivo, Curitiba, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0200-9802","authenticated-orcid":false,"given":"Carlos Afonso","family":"Maestri","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Universidade Positivo, Curitiba, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"ref1","volume-title":"Elimination of cervical cancer as a global health problem is within reach [Internet]","author":"World Health Organization","year":"2018"},{"key":"ref2","volume-title":"Divis\u00e3o de Detec\u00e7\u00e3o Precoce e Apoio \u00e0 Organiza\u00e7\u00e3o de Rede","author":"Minist\u00e9rio da Sa\u00fade","year":"2016","edition":"2nd ed."},{"issue":"03","key":"ref4","first-page":"30","article-title":"[Performance evaluation of cytology and colposcopy compared with histopathology in screening and diagnosis of cervix lesions]","volume":"40","author":"M E Stofler","year":"2011","journal-title":"ACM Arq Catarin Med."},{"issue":"01","key":"ref5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5533\/2177-8264-201224113","article-title":"[CIN: from pathological aspects to the efficiency of the methods used in screening and follow up]","volume":"24","author":"F V Fonseca","year":"2012","journal-title":"DST J Bras Doen\u00e7as Sex Transm."},{"key":"ref6","volume-title":"[Performance of diagnostic methods for the evaluation of the endocervical canal in patients with altered cytology: a meta-analysis] [thesis]","author":"N R Barbosa","year":"2016"},{"issue":"01","key":"ref7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1590\/1516-3180.2019.0435.R1.19112019","article-title":"Accuracy of endocervical cytological tests in diagnosing preinvasive lesions of the cervical canal in patients with type 3 transformation zone: a retrospective observational study","volume":"138","author":"P M Jord\u00e3o","year":"2020","journal-title":"Sao Paulo Med J"},{"issue":"05","key":"ref8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1200\/JGO.2016.006577","article-title":"Secondary prevention and cervical cancer: ASCO resource-stratified clinical practice guideline","volume":"3","author":"J Jeronimo","year":"2016","journal-title":"J Glob Oncol"},{"issue":"02","key":"ref10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.22278\/2318-2660.2017.v41.n2.a2244","article-title":"[Accuracy of vaginal cytology and colposcopy for the diagnosis of cervical intraepithelial neoplasia in Cican-Bahia]","volume":"41","author":"A N Silva","year":"2017","journal-title":"Rev Baiana Sa\u00fade P\u00fablica."},{"issue":"05","key":"ref11","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1590\/S0103-21002012000500005","article-title":"Analysis of the capacity of preventive diagnostic tests for cervical cancer","volume":"25","author":"T H Lima","year":"2012","journal-title":"Acta Paul Enferm"},{"issue":"01","key":"ref12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1177\/0049475518798532","article-title":"Pap smear accuracy for the diagnosis of cervical precancerous lesions","volume":"49","author":"E Nkwabong","year":"2019","journal-title":"Trop Doct"},{"issue":"11","key":"ref13","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1590\/s0100-72032011001100003","article-title":"[High-grade intraepithelial cervical lesions: evaluation of the factors determining an unfavorable outcome after conization]","volume":"33","author":"F V Fonseca","year":"2011","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"01","key":"ref14","first-page":"3","article-title":"[Quantitative analysis of new positive cervical oncoscopy in patients that were submitted to conization and its associated factors]","volume":"2","author":"B R Rosa","year":"2018","journal-title":"Rev Fac Med Teres\u00f3polis"},{"issue":"01","key":"ref15","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ygyno.2020.01.023","article-title":"The risk of cervical cancer after cervical intraepithelial neoplasia grade 3: A population-based cohort study with 80,442 women","volume":"157","author":"D L Loopik","year":"2020","journal-title":"Gynecol Oncol"},{"issue":"02","key":"ref16","first-page":"1029","article-title":"A review of cervical cancer precursor lesions and recurrence after treatment: what are the real risk factors","volume":"3","author":"N S Carvalho","year":"2020","journal-title":"J Gynecol Oncol"}],"container-title":["Revista Brasileira 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