{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:11:33Z","timestamp":1788790293445,"version":"build-2803163510"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"NIH\/ORWH Building Interdisciplinary Research Careers in Women's Health","award":["NIH K12HD043441"],"award-info":[{"award-number":["NIH K12HD043441"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n            Objective\u2003Low-dose aspirin is recommended for preeclampsia prevention among women with high-risk conditions, including chronic hypertension. Black women have higher rates of hypertensive disorders of pregnancy, and whether this is related to disparities in aspirin prophylaxis is unknown. We investigated the relationship between race and counseling\/prescription and uptake of aspirin among a cohort of women with chronic hypertension.<\/jats:p><jats:p>\n            Study Design\u2003This is a single-institution, retrospective cohort study of women with chronic hypertension who delivered between 2016 and 2018. Medical record review was performed to assess counseling\/prescription of aspirin prophylaxis and self-reported uptake. Self-reported uptake was determined by mention in the provider's notes or by inclusion in the medication reconciliation system. Demographic and obstetric outcome data were compared by self-reported race (Black vs. all other races) in univariate analysis. Multivariable logistic regression analysis was performed to evaluate the association between race and aspirin adherence.<\/jats:p><jats:p>\n            Results\u2003We included 872 women: 361 (41.4%) Black women and 511 (58.6%) white or other race women. Overall, 567 (65.0%) women were counseled and\/or given a prescription for aspirin, and 411 (72.4%) of those women reported uptake. Black women were equally likely to be counseled and\/or prescribed aspirin compared with all other races (67.3 vs. 63.4%; p\u2009=\u20090.7). However, Black women were less likely to report uptake of aspirin (63.8 vs. 79.0%; p\u2009&lt;\u20090.001). After adjustment for total prenatal visits and tobacco use, Black race was associated with an adjusted odds ratio of 0.53 (95% confidence interval: 0.36\u20130.78) for uptake of aspirin.<\/jats:p><jats:p>\n            Conclusion\u2003In our cohort, recommendation for aspirin prophylaxis was suboptimal in all groups, reaching only 65% of eligible women. Black women were equally likely as women of other races to receive counseling about aspirin, but rates of uptake were lower. Our findings suggest that counseling and prescription of aspirin alone in high-risk Black women are not sufficient for utilization of this intervention.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0042-1743142","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:03:10Z","timestamp":1645488190000},"page":"635-640","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of Racial Disparities in Aspirin Prophylaxis for Preeclampsia Prevention"],"prefix":"10.1055","volume":"41","author":[{"given":"Nina W.","family":"Ragunanthan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Lamb","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisse","family":"Hauspurg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ajh.2008.20","article-title":"Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987-2004","volume":"21","author":"A B Wallis","year":"2008","journal-title":"Am J Hypertens"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"L Duley","year":"2009","journal-title":"Semin Perinatol"},{"issue":"02","key":"ref3","first-page":"CD004659","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","author":"L Duley","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7326\/M13-2844","article-title":"Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force","volume":"160","author":"J T Henderson","year":"2014","journal-title":"Ann Intern Med"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7326\/M14-1884","article-title":"Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement","volume":"161","author":"M L LeFevre","year":"2014","journal-title":"Ann Intern Med"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/AOG.0000000000002708","article-title":"ACOG Committee Opinion No. 743: low-dose aspirin use during pregnancy","volume":"132","author":"ACOG Committee Opinion No","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0029-7844(95)00480-7","article-title":"Maternal hypertension and associated pregnancy complications among African-American and other women in the United States","volume":"87","author":"A R Samadi","year":"1996","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref8","first-page":"492","article-title":"Disparities in maternal outcomes among four ethnic populations","volume":"15","author":"J J Shen","year":"2005","journal-title":"Ethn Dis"},{"issue":"03","key":"ref9","first-page":"283","article-title":"Racial\/ethnic differences in pregnancy-related hypertensive disease in nulliparous women","volume":"24","author":"G Ghosh","year":"2014","journal-title":"Ethn Dis"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3109\/10641955.2015.1090581","article-title":"Racial disparities in comorbidities, complications, and maternal and fetal outcomes in women with preeclampsia\/eclampsia","volume":"34","author":"S Shahul","year":"2015","journal-title":"Hypertens Pregnancy"},{"issue":"21","key":"ref11","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1080\/14767058.2019.1581522","article-title":"Preeclampsia outcomes at delivery and race","volume":"33","author":"C Gyamfi-Bannerman","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2105\/AJPH.2005.072975","article-title":"The Black-White disparity in pregnancy-related mortality from 5 conditions: differences in prevalence and case-fatality rates","volume":"97","author":"M J Tucker","year":"2007","journal-title":"Am J Public Health"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ajog.2009.10.864","article-title":"Racial\/ethnic disparities in obstetric outcomes and care: prevalence and determinants","volume":"202","author":"A S Bryant","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1097\/AOG.0000000000000735","article-title":"Racial and ethnic disparities in maternal morbidity and obstetric care","volume":"125","author":"W A Grobman","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/AOG.0000000000000564","article-title":"Pregnancy-related mortality in the United States, 2006-2010","volume":"125","author":"A A Creanga","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1097\/AOG.0000000000002937","article-title":"Racial and ethnic disparities in the incidence of severe maternal morbidity in the United States, 2012\u20132015","volume":"132","author":"L K Admon","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref17","first-page":"374.e1","article-title":"Racial and ethnic disparities in use of 17-alpha hydroxyprogesterone caproate for prevention of preterm birth Presented orally (abstract no. 18) at the 36th annual meeting of the Society for Maternal-Fetal Medicine, Atlanta, GA, Feb. 1\u20136, 2016","volume":"214","author":"L M Yee","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref18","first-page":"17","article-title":"Racial differences in adherence to cardiac medications","volume":"95","author":"H Charles","year":"2003","journal-title":"J Natl Med Assoc"},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.placenta.2015.03.001","article-title":"Placental pathology measures: can they be rapidly and reliably integrated into large-scale perinatal studies?","volume":"36","author":"J M Catov","year":"2015","journal-title":"Placenta"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"419.e1","DOI":"10.1016\/j.ajog.2020.03.004","article-title":"Impact of the ACOG guideline regarding low-dose aspirin for prevention of superimposed preeclampsia in women with chronic hypertension","volume":"223","author":"C Banala","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"e006328","DOI":"10.1161\/JAHA.117.006328","article-title":"Contemporary primary prevention aspirin use by cardiovascular disease risk: impact of US Preventive Services Task Force recommendations, 2007-2015: a serial, cross-sectional study","volume":"6","author":"J R Van't Hof","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.2105\/AJPH.94.12.2084","article-title":"Patient race\/ethnicity and quality of patient-physician communication during medical visits","volume":"94","author":"R L Johnson","year":"2004","journal-title":"Am J Public Health"},{"issue":"10","key":"ref23","first-page":"380","article-title":"Time use in clinical encounters: are African-American patients treated differently?","volume":"93","author":"M N Oliver","year":"2001","journal-title":"J Natl Med Assoc"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40615-017-0350-4","article-title":"The effects of race and racial concordance on patient-physician communication: a systematic review of the literature","volume":"5","author":"M J Shen","year":"2018","journal-title":"J Racial Ethn Health Disparities"},{"issue":"07","key":"ref25","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/MLR.0b013e318215d93c","article-title":"Impact of perceived discrimination in healthcare on patient-provider communication","volume":"49","author":"L RM Hausmann","year":"2011","journal-title":"Med Care"},{"key":"ref26","volume-title":"Assessing potential sources of racial and ethnic disparities in care: the clinical encounter","author":"Institute of Medicine (US) Committee on Understanding and Eliminating Racial and Ethnic Disparities in Health Care","year":"2003"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1586\/erc.12.138","article-title":"Enhancing adherence of antihypertensive regimens in hypertensive African-Americans: current and future prospects","volume":"10","author":"L M Lewis","year":"2012","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1007\/s11606-010-1424-8","article-title":"Adherence to cardiovascular disease medications: does patient-provider race\/ethnicity and language concordance matter?","volume":"25","author":"A H Traylor","year":"2010","journal-title":"J Gen Intern Med"},{"issue":"02","key":"ref29","doi-asserted-by":"crossref","first-page":"e0229622","DOI":"10.1371\/journal.pone.0229622","article-title":"Factors that influence adherence to aspirin therapy in the prevention of preeclampsia amongst high-risk pregnant women: a mixed method analysis","volume":"15","author":"R 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