{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:56:54Z","timestamp":1758193014439,"version":"3.44.0"},"reference-count":20,"publisher":"Necmettin Erbakan University Press","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inappropriate antibiotic usage can contribute to the promotion of resistant bacteria. In an effort to reduce antibiotic length of therapy (LOT), we initiated a performance improvement project utilizing pneumonia polymerase chain reaction (PCR) testing in ventilated pediatric intensive care unit (PICU) patients suspected of tracheitis or pneumonia. This was a single-center cohort intervention study that compared pre- and postimplementation patients. The intervention was the use of a pneumonia PCR panel on all PICU patients undergoing an evaluation for acute tracheitis or pneumonia during the postimplementation period. The inclusion criteria were either acute or acute on chronic respiratory failure. After an 8-month period, the charts were reviewed from both cohorts and baseline data, and outcome data were compared by statistical analysis. A total of 41 preimplementation and 30 postimplementation patients were compared, and no baseline differences were found except postimplementation patients being slightly older (133 vs. 56 months, p-value\u2009=\u20090.040). Analysis of the primary outcome measures found that the time to identification of organism (5 vs. 67\u2009hours) and LOT (5 vs. 9 days, p\u2009&lt;\u20090.001) were shorter in postimplementation patients compared with preimplementation patients. Antibiotics were changed based on the results of the pneumonia PCR on 18 of 30 patients (60%). There was no difference in ventilator-free days, PICU length of stay, or mortality. In conclusion, pneumonia PCR panel testing leads to more rapid results and was associated with reduced antibiotic LOT.<\/jats:p>","DOI":"10.1055\/s-0042-1743178","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T20:17:51Z","timestamp":1645215471000},"page":"356-363","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Pneumonia PCR Panel Testing in the PICU: A Quality Improvement Study"],"prefix":"10.53391","volume":"13","author":[{"given":"Yaron","family":"Fireizen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Miller Children's and Women's Hospital of Long Beach, University of California, Irvine School of Medicine, Irvine, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-1052","authenticated-orcid":false,"given":"Christopher J.","family":"Babbitt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Critical Care, Miller Children's and Women's Hospital of Long Beach, Long Beach, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pharmacy, Miller Children's and Women's Hospital of Long Beach, Long Beach, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tricia","family":"Morphew","sequence":"additional","affiliation":[{"name":"Morphew Consulting LLC, Bothell, Washington, United States"},{"name":"MemorialCare Health System, Fountain Valley, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel T.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Long Beach Memorial Medical Center, Long Beach, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inderpal","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Miller Children's and Women's Hospital of Long Beach, University of California, Irvine School of Medicine, Irvine, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.21037\/jtd.2016.12.89","article-title":"Duration of antibiotic therapy in the intensive care unit","volume":"8","author":"G Zilahi","year":"2016","journal-title":"J Thorac Dis"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/PCC.0000000000001925","article-title":"Does an antimicrobial time-out impact the duration of therapy of antimicrobials in the PICU?","volume":"20","author":"S M 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