{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:40:43Z","timestamp":1791463243884,"version":"4.3.4"},"reference-count":13,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Objectives<\/jats:bold>\u2003This article describes the clinical outcomes after thymectomy in patients with thymomatous myasthenia gravis (T-MG) managed in the department of thoracic surgery of Hassan II University Hospital of Fez, Fez, Morocco.<\/jats:p>\n<jats:p>\n<jats:bold>Materials and Methods<\/jats:bold>\u2003We performed a retrospective analysis of medical records of 16 patients with T-MG between January 2009 and January 2017.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003There were 11 women and 5 men with a median age of 40 years at the thymectomy time and a median time of onset of symptoms to thymectomy of 12 months. At the preoperative evaluation (Myasthenia Gravis Foundation of America [MGFA] clinical classification), 7 patients were class II, 7 class III, and 2 class IV. Nine patients were in Masaoka stage I, and the remaining 7 patients stage II. We recorded one case of postoperative myasthenic crisis. At 3 years of follow-up after thymectomy, 6 patients had complete stable remission and the other 10 patients improved. Of these patients with clinical improvement, 6 patients were in MGFA class I and the remaining 4 patients class II.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003The present study shows the beneficial effect of thymectomy in patients with T-MG. Postoperative clinical outcomes seem to be better when the preoperative severity of myasthenic symptoms is mild (MGFA class II).<\/jats:p>","DOI":"10.1055\/s-0042-1743444","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T23:55:57Z","timestamp":1646870157000},"page":"321-325","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis"],"prefix":"10.25259","volume":"13","author":[{"given":"Sani","family":"Rabiou","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, General Referral Hospital of Niamey, Niamey, Niger"},{"name":"Faculty of Medicine and Pharmacy, Abdou Moumouni University of Niamey, Niamey, Niger"},{"name":"Department of Thoracic Surgery, Hassan II University Teaching Hospital of Fez, Fez, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Toudou-Daouda","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Hospital of Niamey, Niamey, Niger"},{"name":"Department of Neurology, Hassan II University Teaching Hospital of Fez, Fez, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwane","family":"Lakranbi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hassan II University Teaching Hospital of Fez, Fez, Morocco"},{"name":"Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdallah University of Fez, Fez, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Issoufou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, General Referral Hospital of Niamey, Niamey, Niger"},{"name":"Department of Thoracic Surgery, Hassan II University Teaching Hospital of Fez, Fez, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"Ouadnouni","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hassan II University Teaching Hospital of Fez, Fez, Morocco"},{"name":"Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdallah University of Fez, Fez, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Smahi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hassan II University Teaching Hospital of Fez, Fez, Morocco"},{"name":"Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdallah University of Fez, Fez, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"10.1055\/s-0042-1743444\/ref-1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1001\/jama.1941.02820440037009","article-title":"The treatment of myasthenia gravis by removal of the thymus gland","volume":"117","author":"Blalock","year":"1941","journal-title":"JAMA"},{"issue":"6","key":"10.1055\/s-0042-1743444\/ref-2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1056\/NEJMoa1602489","article-title":"Randomized trial of thymectomy in myasthenia gravis","volume":"375","author":"Wolfe","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1055\/s-0042-1743444\/ref-3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.thorsurg.2018.12.011","article-title":"History of thymectomy for myasthenia gravis","volume":"29","author":"Cooper","year":"2019","journal-title":"Thorac Surg Clin"},{"issue":"11","key":"10.1055\/s-0042-1743444\/ref-4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.neurol.2013.01.625","article-title":"Thymoma-associated myasthenia gravis: clinical features and surgical results [in French]","volume":"169","author":"Bouchikh","year":"2013","journal-title":"Rev Neurol 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thymoma","volume":"18","author":"Agasthian","year":"2010","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"10.1055\/s-0042-1743444\/ref-11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jns.2017.10.026","article-title":"Different neurologic outcomes of myasthenia gravis with thymic hyperplasia and thymoma after extended thymectomy: a single center experience","volume":"383","author":"Zheng","year":"2017","journal-title":"J Neurol Sci"},{"issue":"1","key":"10.1055\/s-0042-1743444\/ref-12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.asjsur.2020.10.006","article-title":"Video-assisted thoracoscopic surgery for myasthenia gravis with thymoma: a six-year single-center experience","volume":"44","author":"Nguyen","year":"2021","journal-title":"Asian J Surg"},{"issue":"1","key":"10.1055\/s-0042-1743444\/ref-13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/ejcts\/ezu309","article-title":"Prognostic factors of remission in 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