{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:37:31Z","timestamp":1784068651961,"version":"3.55.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Colon Rectal Surg"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mesenteric panniculitis (MP) is the preferred nomenclature for a continuum of inflammatory diseases of the mesentery. The diagnosis of MP is often based on the appearance of a mass-like structure at the root of the mesentery. Characteristic histology includes focal fat necrosis, chronic inflammation, and sometimes mesenteric fibrosis. At present, robust literature related to diagnosis and management of MP are limited. MP is postulated to be an immune-mediated chronic inflammatory and\/or a paraneoplastic disease. A personal or family history of other autoimmune diseases is commonly apparent. Several inciting events have been identified that possibly act as triggers in the development of the disease. Trauma, abdominal surgery, infection, and various cancers have been associated with mesenteric panniculitis.<\/jats:p><jats:p>There are several diagnostic and histologic criteria that aid in making the diagnosis of MP. The differential diagnosis for a mesenteric mass includes neoplastic disease, and a biopsy may be indicated to rule out other conditions.<\/jats:p><jats:p>While cases of MP with a short duration of symptoms, or spontaneously regression may occur, some patients experience prolonged periods of pain, fever, and alterations in bowel habit, causing significant morbidity. A variety of medical therapies have been suggested for MP. Only two, thalidomide and low-dose naltrexone, have been prospectively evaluated. For patients with chronic MP, good responses to prolonged corticosteroid treatment have been reported. Novel therapies include thalidomide and low-dose naltrexone. Hormonal and immunomodulatory therapies are also used based on small case series, but these treatments may have significant side effects. Surgical intervention is not curative and is avoided except for relief of focal bowel obstruction secondary to fibrotic forms of the disease.<\/jats:p>","DOI":"10.1055\/s-0042-1743588","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T22:30:15Z","timestamp":1660170615000},"page":"342-348","source":"Crossref","is-referenced-by-count":16,"title":["Mesenteric Panniculitis, Sclerosing Mesenteritis and Mesenteric Lipodystrophy: Descriptive Review of a Rare Condition"],"prefix":"10.1055","volume":"35","author":[{"given":"Christopher","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Dachman","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Chicago Hospital, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli D.","family":"Ehrenpreis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Illinois"},{"name":"Department of Medicine, Rosalind Franklin University Medical School, North Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S2468-1253(16)30026-7","article-title":"The mesentery: structure, function, and role in disease","volume":"1","author":"J C Coffey","year":"2016","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"04","key":"ref3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/00000478-199704000-00004","article-title":"Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity?","volume":"21","author":"T S Emory","year":"1997","journal-title":"Am J Surg Pathol"},{"issue":"36","key":"ref4","first-page":"1218","article-title":"Mesenteriale lipodystrophie. [Mesenteric lipodystrophy]","volume":"115","author":"A Kuhrmeier","year":"1985","journal-title":"Schweiz Med Wochenschr"},{"issue":"02","key":"ref5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2214\/ajr.174.2.1740427","article-title":"CT evaluation of mesenteric panniculitis: prevalence and associated diseases","volume":"174","author":"M Daskalogiannaki","year":"2000","journal-title":"Am J Roentgenol"},{"issue":"48","key":"ref6","doi-asserted-by":"publisher","first-page":"10601","DOI":"10.3748\/wjg.v22.i48.10601","article-title":"Clinical significance of mesenteric panniculitis-like abnormalities on abdominal computerized tomography in patients with malignant neoplasms","volume":"22","author":"E D Ehrenpreis","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"02","key":"ref7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12328-017-0716-5","article-title":"Sclerosing mesenteritis: a systematic review of 192 cases","volume":"10","author":"P Sharma","year":"2017","journal-title":"Clin J Gastroenterol"},{"issue":"17","key":"ref8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.21037\/atm.2018.07.01","article-title":"Sclerosing mesenteritis: a comprehensive clinical review","volume":"6","author":"M S Green","year":"2018","journal-title":"Ann Transl Med"},{"issue":"08","key":"ref10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1155\/2001\/462823","article-title":"Treatment of sclerosing mesenteritis with corticosteroids and azathioprine","volume":"15","author":"A Bala","year":"2001","journal-title":"Can J Gastroenterol"},{"issue":"06","key":"ref11","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1148\/rg.1103035010","article-title":"CT findings in sclerosing mesenteritis (panniculitis): spectrum of disease","volume":"23","author":"K M Horton","year":"2003","journal-title":"Radiographics"},{"issue":"02","key":"ref12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.5152\/turkjsurg.2018.3881","article-title":"Approach to the diagnosis and treatment of mesenteric panniculitis from the surgical point of view","volume":"34","author":"C Kaya","year":"2018","journal-title":"Turk J Surg"},{"issue":"06","key":"ref13","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s12328-015-0617-4","article-title":"A case of IgG4-related mesenteritis","volume":"8","author":"E Mori","year":"2015","journal-title":"Clin J Gastroenterol"},{"issue":"02","key":"ref14","doi-asserted-by":"publisher","first-page":"e2147","DOI":"10.7759\/cureus.2147","article-title":"A Case of IgG4-related Sclerosing Mesenteritis","volume":"10","author":"Z Butt","year":"2018","journal-title":"Cureus"},{"issue":"03","key":"ref15","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/pin.12386","article-title":"Sclerosing mesenteritis: a real manifestation or histological mimic of IgG4-related disease?","volume":"66","author":"M O Avincsal","year":"2016","journal-title":"Pathol Int"},{"issue":"04","key":"ref16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1440-1827.2012.02805.x","article-title":"IgG4-related sclerosing mesenteritis: a rare mesenteric disease of unknown etiology","volume":"62","author":"H Minato","year":"2012","journal-title":"Pathol Int"},{"issue":"07","key":"ref17","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/DCR.0b013e318252e286","article-title":"Mesenteric panniculitis: a paraneoplastic phenomenon?","volume":"55","author":"A Wilkes","year":"2012","journal-title":"Dis Colon Rectum"},{"issue":"10","key":"ref18","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1055\/s-0042-110100","article-title":"[Mesenteric panniculitis (MP) in CT - a predictor of malignancy?]","volume":"188","author":"F Scheer","year":"2016","journal-title":"RoFo Fortschr Geb Rontgenstr Nuklearmed"},{"issue":"12","key":"ref19","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1002\/bjs.10229","article-title":"Cohort study of mesenteric panniculitis and its relationship to malignancy","volume":"103","author":"P Buchwald","year":"2016","journal-title":"Br J Surg"},{"issue":"05","key":"ref20","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/MCG.0b013e3182703148","article-title":"Relationship between mesenteric abnormalities on computed tomography and malignancy: clinical findings and outcomes of 359 patients","volume":"47","author":"Z L Smith","year":"2013","journal-title":"J Clin Gastroenterol"},{"issue":"06","key":"ref21","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1097\/00000658-196506000-00006","article-title":"Mesenteric panniculitis: review of 27 cases","volume":"161","author":"W W Ogden II","year":"1965","journal-title":"Ann Surg"},{"issue":"01","key":"ref22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.14309\/crj.2015.95","article-title":"Mesenteric panniculitis associated with Vibrio cholerae infection","volume":"3","author":"G Roginsky","year":"2015","journal-title":"ACG Case Rep J"},{"issue":"03","key":"ref23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.6061\/clinics\/2012(03)16","article-title":"Sclerosing mesenteritis as an unusual cause of fever of unknown origin: a case report and review","volume":"67","author":"V I Avelino-Silva","year":"2012","journal-title":"Clinics (S\u00e3o Paulo)"},{"issue":"S 02","key":"ref24","doi-asserted-by":"publisher","first-page":"E44","DOI":"10.1055\/s-0029-1215259","article-title":"Mesenteric panniculitis following colonoscopy, polypectomy, and epinephrine injection","volume":"42","author":"K J Lee","year":"2010","journal-title":"Endoscopy"},{"issue":"12","key":"ref25","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1046\/j.1365-2036.2002.01383.x","article-title":"A pilot study of thalidomide for patients with symptomatic mesenteric panniculitis","volume":"16","author":"P M Ginsburg","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.cgh.2007.02.032","article-title":"Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients","volume":"5","author":"S Akram","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"03","key":"ref27","doi-asserted-by":"publisher","first-page":"625","DOI":"10.2214\/ajr.172.3.10063848","article-title":"Sclerosing mesenteritis: imaging findings in 17 patients","volume":"172","author":"J M Sabat\u00e9","year":"1999","journal-title":"Am J Roentgenol"},{"issue":"03","key":"ref28","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.diii.2014.12.002","article-title":"Mesenteric panniculitis: still an ambiguous condition","volume":"96","author":"N Badet","year":"2015","journal-title":"Diagn Interv Imaging"},{"issue":"01","key":"ref29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2214\/ajr.167.1.8659422","article-title":"The misty mesentery on CT: differential diagnosis","volume":"167","author":"R E Mindelzun","year":"1996","journal-title":"Am J Roentgenol"},{"issue":"10","key":"ref30","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1097\/00000478-200210000-00006","article-title":"Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis","volume":"26","author":"E Montgomery","year":"2002","journal-title":"Am J Surg Pathol"},{"issue":"05","key":"ref31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.5334\/jbr-btr.659","article-title":"Mesenteric panniculitis. Part 2: prevalence and natural course: MDCT prospective study","volume":"94","author":"B Coulier","year":"2011","journal-title":"JBR-BTR"},{"issue":"04","key":"ref32","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1007\/BF02213123","article-title":"Demonstration of efficacy of combining corticosteroids and colchicine in two patients with idiopathic sclerosing mesenteritis","volume":"41","author":"T G\u00e9n\u00e9reau","year":"1996","journal-title":"Dig Dis Sci"},{"issue":"02","key":"ref33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0016-5085(80)90154-7","article-title":"Successful treatment of a patient with retractile mesenteritis with prednisone and azathioprine","volume":"79","author":"G N Tytgat","year":"1980","journal-title":"Gastroenterology"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/archinte.1986.00360150113013","article-title":"Sclerosing mesenteritis. Response to cyclophosphamide","volume":"146","author":"R W Bush","year":"1986","journal-title":"Arch Intern Med"},{"key":"ref35","volume-title":"Tamoxifen. [Updated 2021 Apr 22]","author":"M C Farrar","year":"2021"},{"issue":"09","key":"ref36","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1097\/MCG.0000000000000398","article-title":"Initial findings of an open-label trial of low-dose naltrexone for symptomatic mesenteric panniculitis","volume":"49","author":"G Roginsky","year":"2015","journal-title":"J Clin Gastroenterol"},{"issue":"02","key":"ref37","first-page":"203","article-title":"Mesenteric panniculitis: review of the leterature and presentation of cases","volume":"81","author":"A L Durst","year":"1977","journal-title":"Surgery"},{"issue":"01","key":"ref38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000213653","article-title":"Normal positron emission tomography-computerized tomogram in a patient with apparent mesenteric panniculitis: biopsy is still the answer","volume":"3","author":"E D Ehrenpreis","year":"2009","journal-title":"Case Rep Gastroenterol"}],"container-title":["Clinics in Colon and Rectal Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1743588.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T22:33:29Z","timestamp":1660170809000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1743588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":36,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,8,10]]},"published-print":{"date-parts":[[2022,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1743588","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1531-0043","1530-9681"],"issn-type":[{"value":"1531-0043","type":"print"},{"value":"1530-9681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}