{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:12:59Z","timestamp":1767154379684,"version":"build-2238731810"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg Rep"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spontaneous spinal subdural hematomas (SSH) are rare occurrences that can occur most commonly secondary to vascular malformations or coagulopathies. Only a small fraction of spontaneous SSHs are caused by acquired coagulation disorders such as leukemia, hemophilia, and thrombocytopenia. This case report describes a patient with a history of Guillain\u2013Barr\u00e9 syndrome (GBS), hemophilia A, and mantle cell lymphoma, on zanubrutinib therapy, a Bruton tyrosine kinase inhibitor associated with a risk of spontaneous hemorrhage. This patient developed a spontaneous spinal subdural hematoma, most likely due to the zanubrutinib therapy and exacerbated due to hemophilia. Treatment was delayed due to the patient's history of GBS that confounded the clinical diagnosis. This case is the first report of a spontaneous SSH in a patient on zanubrutinib, highlighting the need for a high index of suspicion for CNS hemorrhage in patients on Bruton's tyrosine kinase (BTK) inhibitor therapy.<\/jats:p>","DOI":"10.1055\/a-1759-9841","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T18:47:06Z","timestamp":1643914026000},"page":"e19-e22","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous Spinal Subdural Hematoma Secondary to Hemophilia A and Zanubrutinib"],"prefix":"10.1055","volume":"83","author":[{"given":"John","family":"Lynes","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Rubino","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh","family":"Gaballa","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien D.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Arrington","sequence":"additional","affiliation":[{"name":"Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Peguero","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-7150","authenticated-orcid":false,"given":"James K. C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States"},{"name":"Department of Oncologic Sciences, University of South Florida Morsani College of Medicine,. Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref1","first-page":"65","article-title":"Nontraumatic acute spinal subdural hematoma: report of five cases and review of the literature","volume":"91","author":"M Domenicucci","year":"1999","journal-title":"J Neurosurg"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/NRL.0000000000000100","article-title":"Spontaneous spinal subdural hematoma","volume":"22","author":"M H de Beer","year":"2017","journal-title":"Neurologist"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.wneu.2015.11.010","article-title":"Predictors of outcome in nontraumatic spontaneous acute spinal subdural hematoma: case report and literature review","volume":"89","author":"B J Pereira","year":"2016","journal-title":"World 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