{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:38:48Z","timestamp":1740166728229,"version":"3.37.3"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Although the role of intraoperative alcoholization of the pituitary gland has been examined for the management of malignant tumor metastases and Rathke's cleft cysts, no such studies have been conducted relating to growth hormone (GH) secreting pituitary tumors, despite the high rate of recurrence in this cohort of patients. Here, we sought to understand the impact of adjunctive intraoperative alcoholization of the pituitary gland on recurrence rates and perioperative complications associated with resection of GH-secreting tumors.<\/jats:p><jats:p>\n          Methods\u2003This is a single-institution retrospective cohort study analyzing recurrence rates and complications among patients with GH-secreting tumors who received intraoperative alcoholization of the pituitary gland postresection versus those that did not. Welch's t-tests and analysis of variance (ANOVA) analyses were employed to compare continuous variables between groups, whereas chi-squared tests for independence or Fisher's exact tests were used for comparing categorical variables.<\/jats:p><jats:p>\n          Results\u2003A total of 42 patients (n\u2009=\u200922 no alcohol and n\u2009=\u200920 alcohol) were included in the final analysis. The overall recurrence rates did not significantly differ between the alcohol and no alcohol groups (35 and 22.7%, respectively; p\u2009=\u20090.59). The average time to recurrence in the alcohol and no alcohol groups was 22.9 and 39 months, respectively (p\u2009=\u20090.63), with a mean follow-up of 41.2 and 53.5 months (p\u2009=\u20090.34). Complications, including diabetes insipidus, were not significantly different between the alcohol and no alcohol groups (30.0 vs. 27.2%, p\u2009=\u20090.99).<\/jats:p><jats:p>\n          Conclusion\u2003Intraoperative alcoholization of the pituitary gland after resection of GH-secreting pituitary adenomas does not reduce recurrence rates or increase perioperative complications.<\/jats:p>","DOI":"10.1055\/s-0042-1744129","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T07:07:40Z","timestamp":1646636860000},"page":"164-169","source":"Crossref","is-referenced-by-count":1,"title":["Intraoperative Alcoholization of the Pituitary Gland Does Not Reduce the Recurrence Rate of Growth Hormone Secreting Pituitary Adenomas"],"prefix":"10.1055","volume":"84","author":[{"given":"Amarbir S.","family":"Gill","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorgen","family":"Sumsion","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0422-7937","authenticated-orcid":false,"given":"Michael","family":"Karsy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-0053","authenticated-orcid":false,"given":"William T.","family":"Couldwell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah T.","family":"Menacho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3171\/jns.1998.88.5.0923","article-title":"Tumor devascularization by intratumoral ethanol injection during surgery. Technical note","volume":"88","author":"R R Lonser","year":"1998","journal-title":"J Neurosurg"},{"issue":"04","key":"ref2","first-page":"435","article-title":"Alcoholization of the pituitary gland in diverse types of neoplasms","volume":"12","author":"T Greco","year":"1965","journal-title":"Osp Ital Chir"},{"key":"ref3","first-page":"54","article-title":"Alcoholization of the pituitary gland. advantages of this method in the treatment of advanced malignant tumors and of their recurrence","volume":"19","author":"T Greco","year":"1965","journal-title":"Urol Int"},{"key":"ref4","first-page":"47","article-title":"Alcoholization of the pituitary gland in the treatment of prostatic cancer","volume":"19","author":"F Sorrentino","year":"1965","journal-title":"Urol Int"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2044.1984.tb07357.x","article-title":"Pituitary alcohol injection for cancer pain. 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A review of ethyl alcohol ablation of the anterior pituitary in a regional pain relief unit","volume":"53","author":"J W Lloyd","year":"1981","journal-title":"Br J Anaesth"},{"issue":"17","key":"ref9","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.4236\/ijcm.2014.517142","article-title":"Transsphenoidal surgery for secreting pituitary microadenomas: results with intraoperative application of absolute alcohol","volume":"5","author":"M F Fraioli","year":"2014","journal-title":"Int J Clin Med"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s00701-017-3318-6","article-title":"Microsurgical versus endoscopic transsphenoidal resection for acromegaly: a systematic review of outcomes and complications","volume":"159","author":"C J Chen","year":"2017","journal-title":"Acta Neurochir (Wien)"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11154-020-09588-z","article-title":"Multidisciplinary management of acromegaly: a consensus","volume":"21","author":"A Giustina","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.nec.2019.05.009","article-title":"Endocrine outcomes after pituitary surgery","volume":"30","author":"A Buttan","year":"2019","journal-title":"Neurosurg Clin N Am"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12020-017-1458-3","article-title":"Microsurgical therapy of pituitary adenomas","volume":"59","author":"P Mortini","year":"2018","journal-title":"Endocrine"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11102-020-01091-7","article-title":"A Pituitary Society update to acromegaly management guidelines","volume":"24","author":"M Fleseriu","year":"2021","journal-title":"Pituitary"},{"issue":"08","key":"ref15","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1210\/jc.2013-1036","article-title":"Endoscopic vs microsurgical transsphenoidal surgery for acromegaly: outcomes in a concurrent series of patients using modern criteria for remission","volume":"98","author":"R M Starke","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3171\/2019.6.JNS191187","article-title":"Long-term outcomes of transsphenoidal surgery for management of growth hormone-secreting adenomas: single-center results","volume":"133","author":"M J Asha","year":"2019","journal-title":"J Neurosurg"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3171\/jns.2004.101.4.0577","article-title":"Surgery for Rathke cleft cysts: technical considerations and outcomes","volume":"101","author":"R J Benveniste","year":"2004","journal-title":"J Neurosurg"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3171\/2010.7.JNS091793","article-title":"Transsphenoidal resection of 82 Rathke cleft cysts: limited value of alcohol cauterization in reducing recurrence rates","volume":"114","author":"K O Lillehei","year":"2011","journal-title":"J Neurosurg"}],"container-title":["Journal of Neurological Surgery Part B: Skull Base"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1744129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:31:41Z","timestamp":1678235501000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1744129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":18,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,3,7]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1744129","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6331","2193-634X"],"issn-type":[{"type":"print","value":"2193-6331"},{"type":"electronic","value":"2193-634X"}],"subject":[],"published":{"date-parts":[[2022,3,4]]}}}