{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:40:17Z","timestamp":1787060417260,"version":"build-2736575974"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aim\u2003The aim is to study the association between imaging findings in chronic pancreatitis and fecal elastase 1 (FE1) in patients with idiopathic chronic pancreatitis (ICP).<\/jats:p>\n                  <jats:p>Methods\u2003In this retrospective study on a prospectively maintained database of patients with ICP, a radiologist blinded to clinical and laboratory findings reviewed CT and\/or MRI. Findings were documented according to recommendations of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, October 2018. Low FE1 (&lt;100\u2009\u03bcg elastase\/g) was considered diagnostic of pancreatic exocrine insufficiency (PEI). Association between imaging findings and FE1 was studied.<\/jats:p>\n                  <jats:p>Results\u2003In total, 70 patients (M: F\u2009=\u200937:33) with ICP with mean age of 24.2 (SD 6.5) years, range 10 to 37 years and mean disease duration of 5.6 (SD 4.6) years, range 0 to 20 years were included. Mean FE level was 82.5 (SD 120.1), range 5 to 501\u2009\u03bcg elastase\/g. Mean main pancreatic duct (MPD) caliber was 7 (SD 4) mm, range 3 to 21\u2009mm and mean pancreatic parenchymal thickness (PPT) was 13.7 (SD 5.5) mm, range 5 to 27\u2009mm. There was a significant association between FE1 and MPD size, PPT, type of pancreatic calcification; presence of intraductal stones, side branch dilatation on magnetic resonance cholangiopancreatography and extent of pancreatic involvement (p &lt;0.05). In total, 79%, 86%, and 78% with moderate to severe MPD dilatation, pancreatic atrophy, and side branch dilatation had low FE1, respectively. But nearly half of those with no or mild structural abnormality on imaging had low FE1.<\/jats:p>\n                  <jats:p>Conclusion\u2003Significant association between FE1 and specific imaging findings demonstrates its potential as a marker of exocrine insufficiency and disease severity in chronic pancreatitis. But imaging and FE1 are complementary rather than supplementary.<\/jats:p>","DOI":"10.1055\/s-0042-1744138","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T19:05:29Z","timestamp":1656011129000},"page":"182-190","source":"Crossref","is-referenced-by-count":12,"title":["How Are Imaging Findings Associated with Exocrine Insufficiency in Idiopathic Chronic Pancreatitis?"],"prefix":"10.1055","volume":"32","author":[{"given":"Ranjan","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Radiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Kumbhar","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajith","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicta","family":"Pearlin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta Dhar","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Chandramohan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(20)31318-0","article-title":"Chronic pancreatitis","volume":"396","author":"G Beyer","year":"2020","journal-title":"Lancet"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0039-6109(05)70046-3","article-title":"Diagnosis of chronic pancreatitis. 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