{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:49:38Z","timestamp":1780087778173,"version":"3.54.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Platelet-rich plasma (PRP) has garnered widespread and increasing attention in recent years. We aimed to characterize the most influential articles in PRP research while clarifying controversies surrounding its use and clinical efficacy and identifying important areas on which to focus future research efforts. The Science Citation Index Expanded subsection of the Web of Science Core Collection was systematically searched to identify the top 50 cited publications on orthopedic PRP research. Publication and study characteristics were extracted, and Spearman's correlations were calculated to assess the relationship between citation data and level of evidence. The top 50 articles were published between the years 2005 and 2016, with 68% published in the year 2010 or later. Of the 33 studies for which level of evidence was assessed, the majority were of level I or II (18, 54.5%). Seventeen articles (34%) were classified as basic science. All clinical studies were prospective, and most (12 studies, 60%) included a high number of metrics related to the PRP preparation protocol and composition. Knee osteoarthritis was the most common topic among clinical studies in the top 50 cited articles (11 studies, 34%). More recent articles were associated with higher citation rates (\u03c1\u2009=\u20090.46, p\u2009&lt;\u20090.001). The most influential articles on orthopaedic PRP research are recent and consist of high\u2013level of evidence studies mostly. Randomized controlled trials were the most common study type, while basic science articles were relatively less common. The most influential clinical studies reported a high number of metrics related to their PRP preparation protocol and the final PRP composition. These results suggest a rapidly evolving field with the potential to better explain inconsistent clinical results with improved understanding and documentation of basic science concepts such as PRP composition, preparation, and combination techniques.<\/jats:p>","DOI":"10.1055\/s-0042-1744223","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:05:03Z","timestamp":1646957103000},"page":"900-910","source":"Crossref","is-referenced-by-count":4,"title":["Influential Studies in Orthopaedic Platelet-Rich Plasma Research Are Recent and Consist of High Levels of Evidence: A Review of the Top 50 Most Cited Publications"],"prefix":"10.1055","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-4373","authenticated-orcid":false,"given":"Jacob F.","family":"Oeding","sequence":"additional","affiliation":[{"name":"School of Medicine, New York University Grossman School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew A.","family":"Lansdown","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Leucht","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, New York University Langone Orthopedic Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph A.","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, New York University Langone Orthopedic Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn","family":"Konopka","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, New York University Langone Orthopedic Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudette M.","family":"Lajam","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, New York University Langone Orthopedic Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/jor.23058","article-title":"Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold","volume":"34","author":"B A Kelly","year":"2016","journal-title":"J Orthop Res"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/ten.teb.2013.0317","article-title":"Application of platelet-rich plasma and platelet-rich fibrin in fat grafting: basic science and literature review","volume":"20","author":"H T Liao","year":"2014","journal-title":"Tissue Eng Part B Rev"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/sj.bjp.0706975","article-title":"Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation","volume":"150","author":"S Asfaha","year":"2007","journal-title":"Br J Pharmacol"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00011-011-0353-2","article-title":"Blood-derived anti-inflammatory protein solution blocks the effect of IL-1\u03b2 on human macrophages in vitro","volume":"60","author":"K M O'Shaughnessey","year":"2011","journal-title":"Inflamm Res"},{"issue":"09","key":"ref5","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00167-013-2743-1","article-title":"Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration","volume":"23","author":"G Filardo","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3109\/14764172.2014.949274","article-title":"Evaluation of effects of platelet-rich plasma on human facial skin","volume":"16","author":"E P Yuksel","year":"2014","journal-title":"J Cosmet Laser Ther"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/jor.22853","article-title":"Tendon regeneration and scar formation: the concept of scarless healing","volume":"33","author":"L M Galatz","year":"2015","journal-title":"J Orthop Res"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nrrheum.2015.26","article-title":"Tendon injury: from biology to tendon repair","volume":"11","author":"G Nourissat","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bmb\/ldu007","article-title":"Platelet-rich plasma in the conservative treatment of painful tendinopathy: a systematic review and meta-analysis of controlled studies","volume":"110","author":"I Andia","year":"2014","journal-title":"Br Med Bull"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1177\/0363546515572777","article-title":"Platelet-rich plasma reduces retear rates after arthroscopic repair of small- and medium-sized rotator cuff tears but is not cost-effective","volume":"43","author":"P Vavken","year":"2015","journal-title":"Am J Sports Med"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2106\/JBJS.K.00154","article-title":"Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis","volume":"94","author":"U Sheth","year":"2012","journal-title":"J Bone Joint Surg Am"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1177\/0363546517743746","article-title":"The efficacy of platelet-rich plasma on tendon and ligament healing: a systematic review and meta-analysis with bias assessment","volume":"46","author":"X Chen","year":"2018","journal-title":"Am J Sports Med"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.arthro.2021.01.039","article-title":"The top 100 most-cited articles on arthroscopy: most popular topic is rotator cuff rather than cartilage in the last 5 years","volume":"37","author":"N Tang","year":"2021","journal-title":"Arthroscopy"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1615\/JLongTermEffMedImplants.2018029379","article-title":"The most cited original articles on anterior cruciate ligament injuries in the past 20 years","volume":"28","author":"P Goljan","year":"2018","journal-title":"J Long Term Eff Med Implants"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-0041-1733881","article-title":"The top 50 most cited publications in meniscus research","volume":"36","author":"K N Kunze","year":"2023","journal-title":"J Knee Surg"},{"issue":"20","key":"ref19","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2106\/JBJS.16.01374","article-title":"A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical orthopaedic literature","volume":"99","author":"J Chahla","year":"2017","journal-title":"J Bone Joint Surg Am"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1177\/0363546506288850","article-title":"Treatment of chronic elbow tendinosis with buffered platelet-rich plasma","volume":"34","author":"A Mishra","year":"2006","journal-title":"Am J Sports Med"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jse.2011.02.008","article-title":"Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up","volume":"20","author":"P Randelli","year":"2011","journal-title":"J Shoulder Elbow Surg"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.asmr.2020.07.024","article-title":"The top 50 most-cited papers in the diagnosis and management of SLAP tears","volume":"3","author":"R Xiao","year":"2021","journal-title":"Arthrosc Sports Med Rehabil"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.arthro.2019.09.031","article-title":"The top 50 most influential articles in hip arthroscopy","volume":"36","author":"J Barbera","year":"2020","journal-title":"Arthroscopy"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1016\/j.asmr.2020.09.011","article-title":"The top 50 most-cited shoulder arthroscopy studies","volume":"3","author":"M L Moore","year":"2021","journal-title":"Arthrosc Sports Med Rehabil"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1089\/biores.2017.0006","article-title":"The top 50 most cited articles in cartilage regeneration","volume":"6","author":"C K Mcdonald","year":"2017","journal-title":"Biores Open Access"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/BPB.0b013e328354b0cf","article-title":"The 50 most cited articles in pediatric orthopedic surgery","volume":"21","author":"K D Baldwin","year":"2012","journal-title":"J Pediatr Orthop B"},{"issue":"22","key":"ref27","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.2106\/JBJS.N.00029","article-title":"The hundred most-cited publications in orthopaedic knee research","volume":"96","author":"S S Ahmad","year":"2014","journal-title":"J Bone Joint Surg Am"},{"issue":"05","key":"ref28","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s11999-010-1604-1","article-title":"100 most cited articles in orthopaedic surgery","volume":"469","author":"K A Lefaivre","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.136.3518.760","article-title":"Historical structure of scientific discovery","volume":"136","author":"T S Kuhn","year":"1962","journal-title":"Science"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1177\/0363546511417792","article-title":"Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma","volume":"39","author":"E A Sundman","year":"2011","journal-title":"Am J Sports Med"},{"issue":"02","key":"ref31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/0363546510387517","article-title":"Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems","volume":"39","author":"T N Castillo","year":"2011","journal-title":"Am J Sports Med"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2106\/JBJS.K.00430","article-title":"Platelet-rich plasma differs according to preparation method and human variability","volume":"94","author":"A D Mazzocca","year":"2012","journal-title":"J Bone Joint Surg Am"},{"issue":"03","key":"ref33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1302\/0301-620X.89B3.18491","article-title":"Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study","volume":"89","author":"T M Bielecki","year":"2007","journal-title":"J Bone Joint Surg Br"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/jor.20519","article-title":"Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus","volume":"26","author":"D JF Moojen","year":"2008","journal-title":"J Orthop Res"},{"issue":"06","key":"ref35","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1177\/0363546512442334","article-title":"Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons","volume":"40","author":"J L Dragoo","year":"2012","journal-title":"Am J Sports Med"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/BOR.0000000000000479","article-title":"Epidemiology of osteoarthritis: literature update","volume":"30","author":"E R Vina","year":"2018","journal-title":"Curr Opin Rheumatol"},{"issue":"02","key":"ref37","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/0363546512471299","article-title":"Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial","volume":"41","author":"S Patel","year":"2013","journal-title":"Am J Sports Med"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1177\/0363546512461902","article-title":"Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis","volume":"40","author":"F Cerza","year":"2012","journal-title":"Am J Sports Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2474-13-229","article-title":"Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial","volume":"13","author":"G Filardo","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1007\/s00167-011-1837-x","article-title":"Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach","volume":"20","author":"G Filardo","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"}],"container-title":["The Journal of Knee Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1744223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T23:52:24Z","timestamp":1686181944000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1744223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":37,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2023,6,7]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1744223","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1538-8506","1938-2480"],"issn-type":[{"value":"1538-8506","type":"print"},{"value":"1938-2480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,10]]}}}