{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:37:13Z","timestamp":1740148633422,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003O objetivo deste estudo foi avaliar a influ\u00eancia da esteriliza\u00e7\u00e3o na resist\u00eancia mec\u00e2nica \u00e0 compress\u00e3o e flex\u00e3o de biocomponentes \u00e0 base de hidroxiapatita obtida a partir de osso bovino liofilizado e sua associa\u00e7\u00e3o com quitosana.<\/jats:p><jats:p>\n          M\u00e9todos\u2003O osso bovino liofilizado foi processado em part\u00edculas de 100 \u03bcm e misturado \u00e0 quitosana em propor\u00e7\u00e3o de 50% de seu peso. A mistura foi acondicionada em moldes met\u00e1licos para preparo dos esp\u00e9cimes e esterilizada a 127\u00b0C em autoclave para posterior experimenta\u00e7\u00e3o. Os esp\u00e9cimes foram submetidos a ensaios de compress\u00e3o e flex\u00e3o seguindo a norma 5833 da International Organization for Standardization (ISO); os esp\u00e9cimes eram blocos cil\u00edndricos de 6\u2009\u00d7\u200912\u2009mm (para ensaios de compress\u00e3o) e placas de 75\u2009\u00d7\u200910\u2009\u00d7\u20093,3\u2009mm (para ensaios de flex\u00e3o). As amostras foram divididas em quatro grupos de 20 esp\u00e9cimes cada, sendo 10 para ensaios de compress\u00e3o e 10 para ensaios de flex\u00e3o. Tr\u00eas grupos foram esterilizados (por autoclavagem, raios gama e \u00f3xido de etileno), enquanto o quarto grupo (controle) n\u00e3o foi. Os testes mec\u00e2nicos obtidos nos diferentes processos de esteriliza\u00e7\u00e3o foram comparados por an\u00e1lise de vari\u00e2ncia (ANOVA, p\u2009&lt;\u20090,05) seguido pelo teste de compara\u00e7\u00e3o m\u00faltipla de m\u00e9dias de Tukey, com intervalo de confian\u00e7a de 95%.<\/jats:p><jats:p>\n          Resultados\u2003Os esp\u00e9cimes apresentaram resist\u00eancias m\u00e9dias \u00e0 compress\u00e3o de 10,25 MPa para o grupo de controle e 3,67 MPa, 9,65 MPa e 9,16 MPa ap\u00f3s esteriliza\u00e7\u00e3o com \u00f3xido de etileno, raios gama e autoclavagem, respectivamente. Os resultados do teste de flex\u00e3o mostraram uma resist\u00eancia m\u00e9dia de 0,40 MPa no grupo de controle, e 0,15 MPa, 0,17 MPa e 0,30 MPa ap\u00f3s esteriliza\u00e7\u00e3o com \u00f3xido de etileno, raios gama e autoclavagem, respectivamente. A compress\u00e3o m\u00e1xima observada no grupo esterilizado com \u00f3xido de etileno foi estatisticamente diferente \u00e0 obtida no grupo de controle (p\u2009=\u20090,0002), esterilizado com raios gama (p\u2009=\u20090,0003) e autoclavado (p\u2009=\u20090,0006). A flex\u00e3o m\u00e1xima dos esp\u00e9cimes esterilizados com raios gama foi estatisticamente diferente \u00e0 observada no grupo de controle (p\u2009=\u20090,0245). No entanto, a resist\u00eancia \u00e0 flex\u00e3o foi baixa em todos os esp\u00e9cimes.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003A esteriliza\u00e7\u00e3o em autoclave n\u00e3o foi associada a diferen\u00e7as estatisticamente significativas nos testes de compress\u00e3o ou flex\u00e3o. Assim, a autoclave foi a melhor op\u00e7\u00e3o de esteriliza\u00e7\u00e3o para os biocomponentes \u00e0 base de hidroxiapatita neste estudo.<\/jats:p>","DOI":"10.1055\/s-0042-1744292","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T22:59:01Z","timestamp":1658530741000},"page":"1051-1059","source":"Crossref","is-referenced-by-count":1,"title":["Biocomponentes \u00e0 base de hidroxiapatita: Influ\u00eancia da esteriliza\u00e7\u00e3o na resist\u00eancia mec\u00e2nica"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8587-5935","authenticated-orcid":false,"given":"Iv\u00e2nio","family":"Tagliari","sequence":"additional","affiliation":[{"name":"Departamento do Ensino e Pesquisa do Hospital S\u00e3o Vicente de Paulo (HSVP) e Instituto de Ortopedia e Traumatologia (IOT). Passo Fundo, RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-0061","authenticated-orcid":false,"given":"Alan Menegaz","family":"Lerner","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-4619","authenticated-orcid":false,"given":"Ant\u00f4nio Louren\u00e7o","family":"Severo","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Coordena\u00e7\u00e3o do Programa de Resid\u00eancia M\u00e9dica em Cirurgia da M\u00e3o e Microcirurgia da Universidade Federal da Fronteira Sul (UFFS), HSVP e IOT, Passo Fundo, RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-2824","authenticated-orcid":false,"given":"Charles Leonardo","family":"Israel","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1590\/S1807-59322008000600016","article-title":"In vitro and in vivo evaluation of lyophilized bovine bone biocompatibility","volume":"63","author":"C R Galia","year":"2008","journal-title":"Clinics (S\u00e3o Paulo)"},{"volume-title":"Aplica\u00e7\u00e3o de tecnologias de manufatura r\u00e1pida ao desenvolvimento integrado de produtos em cl\u00ednicas e ind\u00fastrias de manufatura m\u00e9dica [disserta\u00e7\u00e3o]","year":"2013","author":"F Owusu-Dompreh","key":"ref2"},{"key":"ref3","first-page":"63","volume-title":"Superf\u00edcies dos implantes: o est\u00e1gio atual","author":"E R 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