{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:21:55Z","timestamp":1784604115055,"version":"3.55.0"},"reference-count":79,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuromuscular blocking agents (NMBAs) and prone position (PP) are two major adjunctive therapies that can improve outcome in moderate-to-severe acute respiratory distress syndrome. NMBA should be used once lung-protective mechanical ventilation has been set, for 48\u2009hours or less and as a continuous intravenous infusion. PP should be used as early as possible for long sessions; in COVID-19 its use has exploded. In nonintubated patients, PP might reduce the rate of intubation but not mortality. The goal of this article is to perform a narrative review on the pathophysiological rationale, the clinical effects, and the clinical use and recommendations of both NMBA and PP.<\/jats:p>","DOI":"10.1055\/s-0042-1744304","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T22:35:20Z","timestamp":1653863720000},"page":"453-460","source":"Crossref","is-referenced-by-count":5,"title":["Prone Positioning and Neuromuscular Blocking Agents as Adjunctive Therapies in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome"],"prefix":"10.1055","volume":"43","author":[{"given":"Claude","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Edouard Herriot, Lyon, France"},{"name":"Facult\u00e9 de M\u00e9decine Lyon-Est, Universit\u00e9 de Lyon, Lyon, France"},{"name":"INSERM 955 CNRS 7200, Institut Mondor de Recherches Biom\u00e9dicales, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Cour","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Edouard Herriot, Lyon, France"},{"name":"Facult\u00e9 de M\u00e9decine Lyon-Est, Universit\u00e9 de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Argaud","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Edouard Herriot, Lyon, France"},{"name":"Facult\u00e9 de M\u00e9decine Lyon-Est, Universit\u00e9 de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/01.CCM.0000104114.72614.BC","article-title":"Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute 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