{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:18:50Z","timestamp":1792513130103,"version":"4.5.0"},"reference-count":80,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The definition of acute respiratory distress syndrome (ARDS), has evolved since it was first described in 1967 by Ashbaugh and Petty to the current \u201cBerlin\u201d definition of ARDS developed in 2012 by an expert panel, that provided clarification on the definition of \u201cacute,\u201d and on the cardiac failure criteria. It expanded the definition to include patients receiving non-invasive ventilation, and removed the term \u201cacute lung injury\u201d and added a requirement of patients to be receiving a minimum 5\u2009cmH2O expiratory pressure.<\/jats:p><jats:p>Since 2012, a series of observational cohort studies have generated insights into the utility and robustness of this definition. This review will examine novel insights into the epidemiology of ARDS, failures in ARDS diagnosis, the role of lung imaging in ARDS, the novel ARDS cohort that is not invasively ventilated, lung compliance profiles in patients with ARDS, sex differences that exist in ARDS management and outcomes, the progression of ARDS following initial diagnosis, and the clinical profile and outcomes of confirmed versus resolved ARDS. Furthermore, we will discuss studies that challenge the utility of distinguishing ARDS from other causes of acute hypoxemic respiratory failure (AHRF) and identify issues that may need to be addressed in a revised definition.<\/jats:p>","DOI":"10.1055\/s-0042-1744306","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T22:52:20Z","timestamp":1654815140000},"page":"379-389","source":"Crossref","is-referenced-by-count":4,"title":["Insights Regarding the Berlin Definition of ARDS from Prospective Observational Studies"],"prefix":"10.1055","volume":"43","author":[{"given":"Ciara","family":"Hanley","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Giacomini","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"},{"name":"School of Medicine, National University of Ireland, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairbre","family":"McNicholas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"},{"name":"School of Medicine, National University of Ireland, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Laffey","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"},{"name":"School of Medicine, National University of Ireland, Galway, Ireland"},{"name":"Regenerative Medicine Institute, National University of Ireland, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(67)90168-7","article-title":"Acute respiratory distress in adults","volume":"2","author":"D G Ashbaugh","year":"1967","journal-title":"Lancet"},{"issue":"09","key":"ref2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/milmed\/164.9.653","article-title":"Logistics of parenteral fluids in battlefield resuscitation","volume":"164","author":"F J Pearce","year":"1999","journal-title":"Mil 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Ranieri","year":"2012","journal-title":"JAMA"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/01.ccm.0000435676.68435.56","article-title":"Impact of distinct definitions of acute lung injury on its incidence and outcomes in Brazilian ICUs: prospective evaluation of 7,133 patients*","volume":"42","author":"E B Caser","year":"2014","journal-title":"Crit Care Med"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1164\/ajrccm.159.6.9808136","article-title":"Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland","volume":"159","author":"O R Luhr","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1164\/ajrccm.165.4.2101124","article-title":"Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three 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Sjoding","year":"2018","journal-title":"Chest"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1164\/ajrccm.161.1.9809003","article-title":"Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome","volume":"161","author":"M O Meade","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jcrc.2012.12.002","article-title":"Accuracy of the chest radiograph to identify bilateral pulmonary infiltrates consistent with the diagnosis of acute respiratory distress syndrome using computed tomography as reference standard","volume":"28","author":"J B Figueroa-Casas","year":"2013","journal-title":"J Crit Care"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000542-200401000-00006","article-title":"Comparative diagnostic performances of auscultation, chest 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critically ill","volume":"4","author":"D A Lichtenstein","year":"2014","journal-title":"Ann Intensive Care"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"1909521","DOI":"10.1080\/20018525.2021.1909521","article-title":"Lung ultrasound may be a valuable aid in decision making for patients admitted with COVID-19 disease","volume":"8","author":"C Falster","year":"2021","journal-title":"Eur Clin Respir J"},{"issue":"05","key":"ref39","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.hrtlng.2021.05.003","article-title":"Lung ultrasound score as a tool to monitor disease progression and detect ventilator-associated pneumonia during COVID-19-associated ARDS","volume":"50","author":"A Dargent","year":"2021","journal-title":"Heart Lung"},{"issue":"03","key":"ref40","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1164\/rccm.201003-0369OC","article-title":"Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment","volume":"183","author":"B Bouhemad","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"01","key":"ref41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1164\/rccm.201503-0584OC","article-title":"Hospital incidence and outcomes of the acute respiratory distress syndrome using the Kigali modification of the Berlin definition","volume":"193","author":"E D Riviello","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"02","key":"ref42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1164\/rccm.202009-3575OC","article-title":"Survival in immunocompromised patients ultimately requiring invasive mechanical ventilation: a pooled individual patient data analysis","volume":"204","author":"G Dumas","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"ref43","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1164\/rccm.200301-072OC","article-title":"Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial","volume":"168","author":"M Ferrer","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"01","key":"ref44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.CCM.0000251821.44259.F3","article-title":"A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome","volume":"35","author":"M Antonelli","year":"2007","journal-title":"Crit Care Med"},{"issue":"01","key":"ref45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1164\/rccm.201606-1306OC","article-title":"Non-invasive Ventilation of Patients with ARDS: Insights from the LUNG SAFE Study","volume":"195","author":"G Bellani","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/CCM.0000000000001379","article-title":"Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume","volume":"44","author":"G Carteaux","year":"2016","journal-title":"Crit Care Med"},{"issue":"22","key":"ref47","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1001\/jama.2016.6338","article-title":"Effect of noninvasive ventilation delivered by Helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial","volume":"315","author":"B K Patel","year":"2016","journal-title":"JAMA"},{"issue":"01","key":"ref48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jcrc.2015.10.018","article-title":"Acute respiratory distress syndrome: predictors of noninvasive ventilation failure and intensive care unit mortality in clinical practice","volume":"31","author":"R Chawla","year":"2016","journal-title":"J Crit Care"},{"issue":"02","key":"ref49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/CCM.0000000000002818","article-title":"Predictors of intubation in patients with acute hypoxemic respiratory failure treated with a noninvasive oxygenation strategy","volume":"46","author":"J P Frat","year":"2018","journal-title":"Crit Care Med"},{"issue":"08","key":"ref50","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S2213-2600(21)00105-3","article-title":"The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included?","volume":"9","author":"M A Matthay","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"17","key":"ref51","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1056\/NEJMoa052052","article-title":"Lung recruitment in patients with the acute respiratory distress syndrome","volume":"354","author":"L Gattinoni","year":"2006","journal-title":"N Engl J Med"},{"issue":"06","key":"ref52","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00134-020-06033-2","article-title":"COVID-19 pneumonia: different respiratory treatments for different phenotypes?","volume":"46","author":"L Gattinoni","year":"2020","journal-title":"Intensive Care Med"},{"issue":"02","key":"ref53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1183\/13993003.02195-2020","article-title":"COVID-19 phenotypes: leading or misleading?","volume":"56","author":"L Gattinoni","year":"2020","journal-title":"Eur Respir J"},{"issue":"08","key":"ref54","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S2213-2600(20)30279-4","article-title":"Identification of pathophysiological patterns for triage and respiratory support in COVID-19","volume":"8","author":"L Camporota","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13054-020-03433-0","article-title":"Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study","volume":"25","author":"B Vandenbunder","year":"2021","journal-title":"Crit Care"},{"issue":"12","key":"ref56","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1007\/s00134-020-06192-2","article-title":"Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS","volume":"46","author":"C Ferrando","year":"2020","journal-title":"Intensive Care Med"},{"issue":"09","key":"ref57","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1164\/rccm.202005-2046OC","article-title":"Compliance phenotypes in early acute respiratory distress syndrome before the COVID-19 pandemic","volume":"202","author":"R Panwar","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"323 e321","DOI":"10.1016\/j.jcrc.2011.06.015","article-title":"Risk factors for underuse of lung-protective ventilation in acute lung injury","volume":"27","author":"A J Walkey","year":"2012","journal-title":"J Crit Care"},{"issue":"06","key":"ref59","doi-asserted-by":"crossref","first-page":"R262","DOI":"10.1186\/cc10524","article-title":"Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study","volume":"15","author":"S Han","year":"2011","journal-title":"Crit Care"},{"issue":"08","key":"ref60","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/EJA.0000000000000646","article-title":"Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS\u2014an observational study in 29 countries","volume":"34","author":"LAS VEGAS investigators","year":"2017","journal-title":"Eur J Anaesthesiol"},{"issue":"04","key":"ref61","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1183\/13993003.00609-2019","article-title":"Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study","volume":"54","author":"B A McNicholas","year":"2019","journal-title":"Eur Respir J"},{"issue":"04","key":"ref62","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1183\/13993003.01588-2019","article-title":"Is gender inequity in ventilator management a \u201cwomen's issue\u201d?","volume":"54","author":"M J Schultz","year":"2019","journal-title":"Eur Respir J"},{"issue":"07","key":"ref63","doi-asserted-by":"crossref","first-page":"e0253933","DOI":"10.1371\/journal.pone.0253933","article-title":"Impact of sex on use of low tidal volume ventilation in invasively ventilated ICU patients\u2014a mediation analysis using two observational cohorts","volume":"16","author":"P Swart","year":"2021","journal-title":"PLoS One"},{"issue":"04","key":"ref64","first-page":"878","article-title":"Gender and acute respiratory distress syndrome in critically injured adults: a prospective study","volume":"71","author":"D S Heffernan","year":"2011","journal-title":"J Trauma"},{"issue":"02","key":"ref65","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/ALN.0000000000002508","article-title":"Outcomes of patients presenting with mild acute respiratory distress syndrome: insights from the LUNG SAFE study","volume":"130","author":"T Pham","year":"2019","journal-title":"Anesthesiology"},{"issue":"05","key":"ref66","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s00134-018-5152-6","article-title":"Resolved versus confirmed ARDS after 24\u2009h: insights from the LUNG SAFE study","volume":"44","author":"F Madotto","year":"2018","journal-title":"Intensive Care Med"},{"issue":"11","key":"ref67","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1136\/thoraxjnl-2016-209833","article-title":"Tidal changes on CT and progression of ARDS","volume":"72","author":"M Cereda","year":"2017","journal-title":"Thorax"},{"issue":"09","key":"ref68","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S2213-2600(18)30177-2","article-title":"Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial","volume":"6","author":"C S Calfee","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"05","key":"ref69","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/bja\/aet165","article-title":"ARDS: progress unlikely with non-biological definition","volume":"111","author":"S Fr\u00f6hlich","year":"2013","journal-title":"Br J 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