{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:01:12Z","timestamp":1786971672321,"version":"build-2736575974"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003The aim of this article is to analyze and compare the presence of single-nucleotide polymorphisms (SNPs) of COL1A1 and FGFR2 in class II and class III Javanese populations.<\/jats:p><jats:p>Materials and Methods\u2003Cephalometric radiographs from total 63 patients of class II and III were analyzed. SNP analysis was performed based on both COL1A1 and FGFR2 sequences amplified from total DNA of patients' fresh blood. Principal component analysis was done to calculate the data and find the correlation of the cephalometric indicators influenced by each mutation. t-test and Mann\u2013Whitney analysis were performed to check the significance of differences occurred in each studied parameter (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>Result\u2003There were three COL1A1 SNPs found in class II and only two in class III, while three FGFR2 SNPs found in both classes. Class II phenotype seemed to be strongly influenced by Y-axis and mandibular plane angle, while class III by lower gonial angle and mandibular plane angle.<\/jats:p><jats:p>Conclusion\u2003Based on this study, we suggest that rs2249492 of COL1A1 and rs2981582 of FGFR2 play important roles in class III, while rs2277632 of COL1A1 and rs2981582 of FGFR2 play important role in class II skeletal malocclusion in Javanese population.<\/jats:p>","DOI":"10.1055\/s-0042-1744371","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T23:55:26Z","timestamp":1654646126000},"page":"183-190","source":"Crossref","is-referenced-by-count":7,"title":["COL1A1 and FGFR2 Single-Nucleotide Polymorphisms Found in Class II and Class III Skeletal Malocclusions in Javanese Population"],"prefix":"10.1055","volume":"17","author":[{"given":"I Gusti Aju Wahju","family":"Ardani","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa","family":"Budipramana","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dental Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlina","family":"Rachmawati","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Patera","family":"Nugraha","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Kade Karisma Gita","family":"Ardana","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresia Indah","family":"Budhy","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozita","family":"Hassan","sequence":"additional","affiliation":[{"name":"Orthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia, Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-4799","authenticated-orcid":false,"given":"Dwi","family":"Listyorini","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyanarto","family":"Sarno","sequence":"additional","affiliation":[{"name":"Department of Informatics, Institute Technology of Sepuluh Nopember, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"e422","DOI":"10.1097\/SCS.0000000000003627","article-title":"Genetic factors involved in mandibular prognathism","volume":"28","author":"A Doraczynska-Kowalik","year":"2017","journal-title":"J Craniofac Surg"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ajodo.2013.01.014","article-title":"Changes in the pattern of patients receiving surgical-orthodontic treatment","volume":"143","author":"W R Proffit","year":"2013","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"S 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