{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:58:00Z","timestamp":1740142680096,"version":"3.37.3"},"reference-count":29,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"07","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Ecodiagn\u00f3stico El Bosque S. A. S","award":["PMMFGEB-011"],"award-info":[{"award-number":["PMMFGEB-011"]}]},{"DOI":"10.13039\/100016018","name":"Universidad El Bosque","doi-asserted-by":"crossref","award":["PCI-2013-472"],"award-info":[{"award-number":["PCI-2013-472"]}],"id":[{"id":"10.13039\/100016018","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aims to describe the behavior of chromosomopathy screenings in euploid fetuses.<\/jats:p><jats:p>\n          Methods\u2003This is a prospective descriptive study with 566 patients at 11 to 14 weeks of gestation. The associations between ultrasound scans and serological variables were studied. For the quantitative variables we used the Spearman test; for the qualitative with quantitative variables the of Mann-Whitney U-test; and for qualitative variables, the X2 test was applied. Significance was set at p \u2264 0.05.<\/jats:p><jats:p>\n          Results\u2003We have found that gestational age has correlation with ductus venosus, nuchal translucency, free fraction of \u03b2 subunit of human chorionic gonadotropin, pregnancy-associated plasma protein-A and placental growth factor; there is also a correlation between history of miscarriages and nasal bone. Furthermore, we correlated body mass index with nuchal translucency, free fraction of \u03b2 subunit of human chorionic gonadotropin, and pregnancy-associated plasma protein-A. Maternal age was associated with free fraction of \u03b2 subunit of human chorionic gonadotropin and pregnancy-associated plasma protein-A.<\/jats:p><jats:p>\n          Conclusion\u2003Our study demonstrates for the first time the behavior of the biochemical and ultrasonographic markers of chromosomopathy screenings during the first trimester in euploid fetuses in Colombia. Our information is consistent with international reference values. Moreover, we have shown the correlation of different variables with maternal characteristics to determine the variables that could help with development of a screening process during the first trimester with high detection rates.<\/jats:p>","DOI":"10.1055\/s-0042-1744461","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T22:35:57Z","timestamp":1654554957000},"page":"646-653","source":"Crossref","is-referenced-by-count":0,"title":["Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-2705","authenticated-orcid":false,"given":"Ximena Carolina","family":"Romero Infante","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Ecodiagn\u00f3stico El Bosque SAS, Los Cobos Medical Center, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-8633","authenticated-orcid":false,"given":"Montserrat","family":"Uriel","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Ecodiagn\u00f3stico El Bosque SAS, Los Cobos Medical Center, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6213-5846","authenticated-orcid":false,"given":"Alejandra","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5976-8597","authenticated-orcid":false,"given":"Mar\u00eda Fernanda","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3442-8748","authenticated-orcid":false,"given":"Andres Felipe","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-5450","authenticated-orcid":false,"given":"Laura Catalina","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5801-936X","authenticated-orcid":false,"given":"Jeadran Nevardo","family":"Malag\u00f3n-Rojas","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, Research Group of Community Medicine and Collective Health, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4594-9151","authenticated-orcid":false,"given":"Sara","family":"Rinc\u00f3n Franco","sequence":"additional","affiliation":[{"name":"Universidad El Bosque, El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Ecodiagn\u00f3stico El Bosque SAS, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"102","DOI":"10.18359\/rmed.2764","article-title":"[Prenatal diagnosis of congenital anormalies; an absent policy in Colombia]","volume":"24","author":"G A Restrepo Cano","year":"2016","journal-title":"Rev Fac Med 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