{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:02:48Z","timestamp":1765976568210,"version":"3.37.3"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated whether in patients undergoing off-pump coronary artery bypass grafting surgery a single bolus of 1\u2009g tranexamic acid (TXA) impacts the risk of postoperative delirium using the propensity score matching approach. In 2,757 pairs, the risk of delirium was 4.2% (TXA group) and 5.0% (non-TXA group), with a relative risk in the TXA versus the non-TXA group of 0.83 (95% confidence interval: 0.65\u20131.07; p\u2009=\u20090.16). There was no significant interaction between TXA administration and renal function on the risk of delirium (p\u2009=\u20090.12). Data indicate that a single bolus of 1\u2009g TXA does not increase the risk of delirium in patients undergoing off-pump surgery.<\/jats:p>","DOI":"10.1055\/s-0042-1745811","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T22:33:18Z","timestamp":1654554798000},"page":"051-054","source":"Crossref","is-referenced-by-count":3,"title":["Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery"],"prefix":"10.1055","volume":"72","author":[{"given":"Nikolai","family":"Hulde","sequence":"additional","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-6554","authenticated-orcid":false,"given":"Armin","family":"Zittermann","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus-Andre","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan F.","family":"Gummert","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"von Dossow","sequence":"additional","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Koster","sequence":"additional","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"S K Inouye","year":"2014","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"h2538","DOI":"10.1136\/bmj.h2538","article-title":"Outcome of delirium in critically ill patients: systematic review and meta-analysis","volume":"350","author":"J I 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