{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:28:07Z","timestamp":1751358487979,"version":"3.37.3"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Perinatal hypothyroidism has a negative repercussion on the development and maturation of auditory system function. However, its long-term effect on auditory function remains unsettled.<\/jats:p><jats:p>\n          Objective\u2003To evaluate the effect of prenatal hypothyroidism on the auditory function of adult offspring in rats.<\/jats:p><jats:p>\n          Methods\u2003Pregnant Wistar rats were given the antithyroid drug methimazole (0.02% -1-methylimidazole-2-thiol\u2013 MMI) in drinking water, ad libitum, from gestational day (GD) 9 to postnatal day 15 (PND15). Anesthetized offspring from MMI-treated dams (OMTD) and control rats were evaluated by tympanometry, distortion product otoacoustic emission (DPOAE), and auditory brainstem response (ABR) at PNDs 30, 60, 90, and 120.<\/jats:p><jats:p>\n          Results\u2003Our data demonstrated no middle ear dysfunction, with the OMTD compliance lower than that of the control group. The DPOAE revealed the absence of outer hair cells function, and the ABR showed normal integrity of neural auditory pathways up to brainstem level in the central nervous system. Furthermore, in the OMTD group, hearing loss was characterized by a higher electrophysiological threshold.<\/jats:p><jats:p>\n          Conclusion\u2003Our data suggest that perinatal hypothyroidism leads to irreversible damage to cochlear function in offspring.<\/jats:p>","DOI":"10.1055\/s-0042-1745856","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T23:19:56Z","timestamp":1655248796000},"page":"e712-e717","source":"Crossref","is-referenced-by-count":3,"title":["The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring"],"prefix":"10.1055","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-6167","authenticated-orcid":false,"given":"Priscila Feliciano de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"},{"name":"Department of Speech, Language and Hearing, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"},{"name":"Department of Physiology, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4171-7529","authenticated-orcid":false,"given":"Beatriz Barros Santos","family":"Trindade","sequence":"additional","affiliation":[{"name":"Department of Speech, Language and Hearing, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-7222","authenticated-orcid":false,"given":"Paloma Fonseca Martins","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Speech, Language and Hearing, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-842X","authenticated-orcid":false,"given":"T\u00e2mara Figueiredo do Carmo","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Speech, Language and Hearing, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-3463","authenticated-orcid":false,"given":"Julio Cesar Santana","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"},{"name":"Department of Veterinary Medicine, Faculdade Pio D\u00e9cimo , Aracaju, SE, Brazil"},{"name":"Department of Physiology, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-5770","authenticated-orcid":false,"given":"Demetrius Silva de","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"},{"name":"Department of Science Computation, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-0280","authenticated-orcid":false,"given":"Daniel","family":"Badau\u00ea-Passos Jr","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universidade Federal de Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, 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