{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:37:14Z","timestamp":1740148634145,"version":"3.37.3"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003O presente estudo estimou a propor\u00e7\u00e3o de avascularidade histol\u00f3gica das extremidades das fraturas em caso de pseudoartrose de ossos longos.<\/jats:p><jats:p>\n          M\u00e9todos\u2003No total, 15 casos de pseudoartrose quiescente estabelecida foram operados de acordo com o protocolo padr\u00e3o e as extremidades da fratura foram avaliadas histologicamente. Em resumo, o tecido biopsiado foi fixado em formalina e embebido em parafina (FFPE); sec\u00e7\u00f5es de 5 m\u00edcrons foram coradas com hematoxilina e eosina de acordo com os protocolos padr\u00f5es. A imunohistoqu\u00edmica com anticorpo anti-CD31 (clone JC70A, DBS) foi realizada manualmente segundo protocolos padr\u00f5es.<\/jats:p><jats:p>\n          Resultados\u2003Todos os casos de pseudoartrose quiescente foram inclu\u00eddos; 2 eram de pseudoartrose oligotr\u00f3fica e 13 eram de pseudoartrose atr\u00f3fica \u00e0 radiologia. Destes, 20% eram de pacientes do sexo feminino, 40% de indiv\u00edduos entre 31 e 40 anos de idade e todos os casos eram de pseudoartrose atr\u00f3fica \u00e0 radiologia. Todos os casos eram positivos para CD-31 \u00e0 imunohistoqu\u00edmica. A densidade dos vasos sangu\u00edneos era de categoria I em 13,33% dos casos e de categoria II em 86,67%. Quatro casos apresentavam inflama\u00e7\u00e3o branda e dois apresentavam inflama\u00e7\u00e3o moderada. O n\u00famero m\u00e9dio de vasos era de 10 por campo de alta pot\u00eancia na faixa et\u00e1ria de 20 a 30, de 31 a 40 e de 41 a 50 anos. A faixa et\u00e1ria de 61 a 70 anos apresentava, em m\u00e9dia, 4 vasos por campo de alta pot\u00eancia. A diferen\u00e7a nos n\u00fameros de vasos em pseudoarthroses oligotr\u00f3ficas e atr\u00f3ficas n\u00e3o foi significativa. N\u00e3o houve correla\u00e7\u00e3o entre a densidade de vasos e a dura\u00e7\u00e3o da pseudoartrose.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003A nomenclatura de classifica\u00e7\u00e3o da pseudoartrose em atr\u00f3fica, oligotr\u00f3fica e hipertr\u00f3fica precisa ser revista. Nossos achados n\u00e3o indicam que a pseudoartrose atr\u00f3fica e oligotr\u00f3fica sejam histologicamente diferentes.<\/jats:p>","DOI":"10.1055\/s-0042-1746180","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T22:50:55Z","timestamp":1657147855000},"page":"1045-1050","source":"Crossref","is-referenced-by-count":1,"title":["Pseudoartrose atr\u00f3fica \u00e9 um termo incorreto? \u2013 Um estudo hospitalar transversal prospectivo"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-7148","authenticated-orcid":false,"given":"Sandeep Kumar","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, All India Institute of Medical Sciences, Rishikesh, \u00cdndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-0049","authenticated-orcid":false,"given":"Mohit","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, All India Institute of Medical Sciences, Rishikesh, \u00cdndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-3923","authenticated-orcid":false,"given":"Prashant","family":"Joshi","sequence":"additional","affiliation":[{"name":"Departmento de Patologia, All India Institute of Medical Sciences, Rishikesh, \u00cdndia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","author":"T A Einhorn","year":"1998","journal-title":"Clin Orthop Relat Res"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/ip.2004.005843","article-title":"Epidemiology of lower limb fractures in general practice in the United Kingdom","volume":"10","author":"J A Kaye","year":"2004","journal-title":"Inj Prev"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"e002276","DOI":"10.1136\/bmjopen-2012-002276","article-title":"The relative incidence of fracture non-union in the Scottish population (5.17 million): a 5-year epidemiological study","volume":"3","author":"L A Mills","year":"2013","journal-title":"BMJ Open"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3928\/0147-7447-19880801-06","article-title":"Nonunion of the tibial shaft","volume":"11","author":"S A Green","year":"1988","journal-title":"Orthopedics"},{"issue":"241","key":"ref5","first-page":"146","article-title":"Ilizarov treatment of tibial nonunions with bone loss","author":"D Paley","year":"1989","journal-title":"Clin Orthop Relat Res"},{"volume-title":"Bone Nonunion. [Updated 2021 Mar 17]","year":"2022","author":"J D Thomas","key":"ref6"},{"issue":"105","key":"ref8","first-page":"34","article-title":"Tibial blood supply in relation to fracture healing","author":"F W Rhinelander","year":"1974","journal-title":"Clin Orthop Relat Res"},{"issue":"S 04","key":"ref9","first-page":"S30","article-title":"Classification of non-union [published correction appears in Injury. 2006 Sep;37(9):927. 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