{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:18:11Z","timestamp":1792606691483,"version":"4.5.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003There is an increased risk of arterial events including major adverse cardiovascular events (MACE) and major adverse limb events (MALE) after venous thromboembolism (VTE). However, their risk factors remain little explored.<\/jats:p><jats:p>Methods\u2003We aimed to determine the risk factors for MACE (acute coronary syndrome\/stroke\/cardiovascular death) and MALE (limb ischemia\/critical limb ischemia\/non-traumatic amputation\/any limb revascularization) after VTE. Competing risk models (Fine-Gray) were used in a multicenter prospective cohort of 4,940 patients (mean age: 64.6 years and median follow-up: 64 months).<\/jats:p><jats:p>Results\u2003MACE occurred in 17.3% of participants (2.35% per patient-years) and MALE in 1.7% (0.27% per patient-years). In multivariable analysis, the identified risk factors for MACE were the age of 50 to 65 years (vs. &lt;50 years, hazard ratio [HR]: 2.00, 95% confidence interval [CI]: 1.38\u20132.91), age &gt;65 years (vs. &lt;50 years, HR 4.85, 95% CI: 3.35\u20137.02), pulmonary embolism\u2009+\u2009deep vein thrombosis (DVT) (vs. isolated-DVT, HR: 1.25, 95% CI: 1.02\u20131.55), unprovoked-VTE (vs. transient risk factor associated-VTE, HR: 1.29, 95% CI: 1.04\u20131.59), current tobacco use (vs. never, HR: 1.45, 95% CI: 1.07\u20131.98), hypertension (HR: 1.61, 95% CI: 1.30\u20131.98), past history of symptomatic atherosclerosis (HR: 1.52, 95% CI: 1.17\u20131.98), heart failure (HR: 1.71, 95% CI: 1.21\u20132.42), atrial fibrillation (HR: 1.55, 95% CI: 1.15\u20132.08), and vena cava filter insertion (HR: 1.46, 95% CI: 1.03\u20132.08). The identified risk factors for MALE were the age of 50\u201365 years (vs. &lt;50 years, HR: 3.49, 95% CI: 1.26\u20139.65) and atrial fibrillation (HR: 2.37, 95% CI: 1.15\u20134.89).<\/jats:p><jats:p>Conclusions\u2003Risk factors for MACE and MALE after VTE included some traditional cardiovascular risk factors, patient's comorbidities, and some characteristics of VTE.<\/jats:p>","DOI":"10.1055\/s-0042-1748152","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T22:30:26Z","timestamp":1656628226000},"page":"465-480","source":"Crossref","is-referenced-by-count":6,"title":["Risk Factors for Major Adverse Cardiovascular Events and Major Adverse Limb Events after Venous Thromboembolism: A Large Prospective Cohort Study"],"prefix":"10.1055","volume":"48","author":[{"given":"Steve Raoul","family":"Noumegni","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Didier","sequence":"additional","affiliation":[{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"},{"name":"Department of Cardiology, Brest Teaching Hospital, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mansourati","sequence":"additional","affiliation":[{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"},{"name":"Department of Cardiology, Brest Teaching Hospital, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle Le","family":"Moigne","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael Le","family":"Mao","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire De","family":"Moreuil","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tromeur","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves Le","family":"Roux","sequence":"additional","affiliation":[{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"},{"name":"Department of Nuclear Medicine, Brest Teaching Hospital, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahaa","family":"Nasr","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Brest Teaching Hospital, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Gentric","sequence":"additional","affiliation":[{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"},{"name":"Department of Neuroradiology, Brest Teaching Hospital, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Guegan","sequence":"additional","affiliation":[{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Poulhazan","sequence":"additional","affiliation":[{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Lacut","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Bressollette","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching Hospital, Brest Teaching Hospital, Brest, France"},{"name":"Western Brittany Thrombosis Study Group, Western Brittany University, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Couturaud","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Vascular Medicine and Pneumology, Brest University Teaching 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