{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:26:04Z","timestamp":1783070764568,"version":"3.54.6"},"reference-count":3,"publisher":"Georg Thieme Verlag KG","issue":"16","funder":[{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services >","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"crossref","award":["Solicitation No. FDA-SOL-1233554"],"award-info":[{"award-number":["Solicitation No. FDA-SOL-1233554"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n            Objective\u2003The objective of this study was to describe the acute side effects experienced by pregnant women who received a coronavirus disease 2019 (COVID-19) vaccine in the United States and to compare their experience to nonpregnant women of similar age.<\/jats:p><jats:p>\n            Study Design\u2003Adults who received a COVID-19 vaccine in the United States were invited via social media to enroll in an online, longitudinal, community-based registry (\n              www.helpstopCOVID19.com\n            ). Participants self-reported pregnancy status, vaccination dates, manufacturer, acute side effects, impact on work and self-care, medical consultation, and hospitalization. This analysis was restricted to women aged 20 to 39 at the time of vaccination. Side effects reported by pregnant women were compared to those reported by nonpregnant women.<\/jats:p><jats:p>\n            Results\u2003This analysis included 946 pregnant women, with 572 (60%) receiving at least one dose of Pfizer, 321 (34%) Moderna, and 53 (6%) J&amp;J, and 1,178 nonpregnant women. Demographic and medical history were similar across manufacturers for both cohorts.<\/jats:p><jats:p>Overall, pregnant women reported similar side effects as nonpregnant women, with the most common being injection site reactions (83 vs. 87%), fatigue (72 vs.78%), and headache (45 vs. 59%). Pregnant women reported fewer side effects (median: 3 vs. 4, respectively). In both cohorts, very few reported seeking medical care (&lt;5%) or being hospitalized (&lt;0.3%) after vaccination. Fewer pregnant women reported working less after vaccination than nonpregnant women (32 vs. 40%) or trouble with self-care (32 vs. 46%), respectively.<\/jats:p><jats:p>\n            Conclusion\u2003Pregnant women reported similar COVID-19 vaccine side effects as nonpregnant women, although fewer total side effects; pregnant women judged these side effects to have less impact on work and self-care. While these results do not address pregnancy outcomes or long-term effects, findings about acute side effects and impact offer reassurance for all three vaccines in terms of tolerability.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0042-1748158","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T22:52:35Z","timestamp":1651877555000},"page":"1750-1753","source":"Crossref","is-referenced-by-count":15,"title":["COVID-19 Vaccinations in Pregnancy: Comparative Evaluation of Acute Side Effects and Self-Reported Impact on Quality of Life between Pregnant and Nonpregnant Women in the United States"],"prefix":"10.1055","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-8952","authenticated-orcid":false,"given":"Emma","family":"Brinkley","sequence":"additional","affiliation":[{"name":"IQVIA Real-World Solutions, 201 Broadway, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina DeFilippo","family":"Mack","sequence":"additional","affiliation":[{"name":"IQVIA Real-World Solutions, 201 Broadway, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Albert","sequence":"additional","affiliation":[{"name":"IQVIA Real-World Solutions, 201 Broadway, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Knuth","sequence":"additional","affiliation":[{"name":"IQVIA Real-World Solutions, 201 Broadway, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"IQVIA Real-World Solutions, 201 Broadway, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Toovey","sequence":"additional","affiliation":[{"name":"Pegasus Research, Neuschwaendistrasse 6, 6390 Engelberg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Dreyer","sequence":"additional","affiliation":[{"name":"IQVIA Real-World Solutions, 201 Broadway, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"issue":"24","key":"ref1","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1056\/NEJMoa2104983","article-title":"Preliminary findings of mRNA COVID-19 vaccine safety in pregnant persons","volume":"384","author":"T T Shimabukuro","year":"2021","journal-title":"N Engl J Med"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1080\/14760584.2021.1986390","article-title":"COVID-19 vaccination in pregnant and lactating women: a systematic review","volume":"20","author":"R Falsaperla","year":"2021","journal-title":"Expert Rev Vaccines"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/uog.23729","article-title":"Short-term outcome of pregnant women vaccinated with BNT162b2 mRNA COVID-19 vaccine","volume":"58","author":"S Bookstein Peretz","year":"2021","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1748158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:21:01Z","timestamp":1668817261000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1748158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":3,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,11,18]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1748158","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,6]]}}}