{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:27:37Z","timestamp":1787167657021,"version":"build-2736575974"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/100014386","name":"Abbott Diagnostics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014386","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Massachusetts General Hospital Corrigan Women's Heart Health Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Objective\u2003Whether biomarkers may enable early identification of women who develop peripartum cardiomyopathy (PPCM) prior to disease onset remains a question of interest.<\/jats:p>\n                  <jats:p>Study Design\u2003A retrospective nested case\u2013control study was conducted to determine whether first trimester N-terminal pro-B type natriuretic peptide (NT-proBNP) or high sensitivity cardiac troponin I (hs-cTnI) differed among women who developed PPCM versus unaffected pregnancies. Cases were matched to unaffected women by age, race, parity, and gestational age of sample (control A) and then further by blood pressure and pregnancy weight gain (control B).<\/jats:p>\n                  <jats:p>Results\u2003First trimester NT-proBNP concentrations were numerically higher among women who subsequently developed PPCM (116 pg\/mL [83\u2013177]) as compared with women in control A (56.1 pg\/mL [38.7\u2013118.7], p\u2009=\u20090.3) or control B (37.6 [23.3\u2009\u2212\u200953.8], p &lt;0.05). A higher proportion of women who subsequently developed PPCM (50%) had detectable levels of hs-cTnI as compared with control A (0%, p\u2009=\u20090.03) or control B (18.8%, p\u2009=\u20090.52). Among both cases and controls, hs-cTnI values were low and often below the limit of detection.<\/jats:p>\n                  <jats:p>Conclusion\u2003There were differences in first trimester NT-proBNP and hs-cTnI concentrations between women who subsequently developed PPCM and those who did not, raising the possibility the early pregnancy subclinical myocardial dysfunction may be associated with this late-pregnancy disease.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0042-1748159","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T18:52:35Z","timestamp":1651863155000},"page":"137-140","source":"Crossref","is-referenced-by-count":4,"title":["First Trimester Cardiac Biomarkers among Women with Peripartum Cardiomyopathy: Are There Early Clues to This Late-Pregnancy Phenomenon?"],"prefix":"10.1055","volume":"40","author":[{"given":"Amy A.","family":"Sarma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Januzzi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona T.","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Thadhani","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malissa J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille E.","family":"Powe","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Endocrinology, Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita S.","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jacc.2019.11.014","article-title":"Peripartum cardiomyopathy: JACC state-of-the-art review","volume":"75","author":"M B Davis","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"E60","DOI":"10.1002\/clc.20391","article-title":"Longitudinal changes in the B-type natriuretic peptide levels in normal pregnancy and postpartum","volume":"32","author":"A B Hameed","year":"2009","journal-title":"Clin Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ijcard.2016.11.111","article-title":"Factors influencing brain natriuretic peptide levels in healthy pregnant women","volume":"228","author":"M Mayama","year":"2017","journal-title":"Int J Cardiol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/openhrt-2020-001293","article-title":"Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T","volume":"7","author":"E Furen\u00e4s","year":"2020","journal-title":"Open Heart"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.amjmed.2018.11.017","article-title":"High-sensitivity cardiac troponin i levels in normal and hypertensive pregnancy","volume":"132","author":"J Ravichandran","year":"2019","journal-title":"Am J Med"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijoa.2014.07.005","article-title":"Assessing the incidence of peripartum subclinical myocardial ischemia using the troponin T assay: an observational pilot study","volume":"24","author":"R Smith","year":"2015","journal-title":"Int J Obstet Anesth"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1097\/HJH.0000000000002497","article-title":"High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia","volume":"38","author":"H EC Muijsers","year":"2020","journal-title":"J Hypertens"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cca.2016.10.033","article-title":"N-terminal pro B-type natriuretic peptide and angiogenic biomarkers in the prognosis of adverse outcomes in women with suspected preeclampsia","volume":"463","author":"I \u00c1lvarez-Fern\u00e1ndez","year":"2016","journal-title":"Clin Chim Acta"},{"issue":"26","key":"ref9","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1056\/NEJMc1602671","article-title":"Shared genetic predisposition in peripartum and dilated cardiomyopathies","volume":"374","author":"J S Ware","year":"2016","journal-title":"N Engl J Med"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ajog.2004.12.006","article-title":"Evaluation of B-type natriuretic peptide (BNP) levels in normal and preeclamptic women","volume":"193","author":"J L Resnik","year":"2005","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of 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