{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:15:13Z","timestamp":1791476113638,"version":"4.3.4"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n            Objective\u2003The aim of the study is to investigate the therapeutic effects of astaxanthin (AST) and resveratrol (RVT) on multiorgan damage in an animal model of the supraceliac aortic ischemia-reperfusion (I\/R).<\/jats:p><jats:p>\n            Methods\u2003In this study, 28 rats (n\u2009=\u20097\/group), 200 to 250\u2009g in weight, were randomized to four groups (1: Sham, 2: Control\u2009+\u2009I\/R, 3: AST\u2009+\u2009I\/R, and 4: RVT\u2009+\u2009I\/R). Following the abdominal incision, aortic dissection was performed in the sham group without injury. Other groups underwent I\/R injury via supraceliac aortic clamping (20\u2009minutes) and reperfusion. The rats were administered olive oil (3\u2009mL\/kg) orally for 2 weeks before and 1 week after the laparotomy. Additionally, oral AST (10\u2009mg\/kg) or RVT (50\u2009mg\/kg) was given to the study groups. All rats were sacrificed on the 3rd week of the experiment after blood samples were taken for analysis. Multiple rat tissues were removed.<\/jats:p><jats:p>\n            Results\u2003We found that RVT increased total antioxidant status (TAS) and superoxide dismutase (SOD) levels, and decreased total oxidant status (TOS), oxidative stress index (OSI), myeloperoxidase (MPO), and malondialdehyde (MDA) levels, while AST increased the levels of TAS, decreased TNF-\u03b1, MDA, TOS, and OSI (p &lt;0.05). Pathological investigations of the rat tissues revealed that both AST and RVT ameliorated tissue damage and apoptosis.<\/jats:p><jats:p>\n            Conclusion\u2003Our study suggests that AST and RVT might show therapeutic effects against oxidative tissue damage and apoptosis in an animal model of aortic I\/R. Further studies are required.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0042-1748324","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T22:30:45Z","timestamp":1653863445000},"page":"1069-1076","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic Role of Astaxanthin and Resveratrol in an Experimental Rat Model of Supraceliac Aortic Ischemia-Reperfusion"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-2562","authenticated-orcid":false,"given":"Dilek","family":"Dilli","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130rfan","family":"Ta\u015fo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences of Turkey, T\u00fcrkiye Y\u00fcksek \u0130htisas E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ey\u00fcp","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Management, G\u00fclhane Faculty of Medicine\/Ankara Provincial Health Directorate, University of Health Sciences of Turkey, Public Hospitals Services Presidency, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Akduman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihat","family":"Yumu\u015fak","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Harran University, \u015eanl\u0131urfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim Boran","family":"T\u00fcmer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences of Turkey, T\u00fcrkiye Y\u00fcksek \u0130htisas E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih","family":"Salar","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Saki Yenilli Experimental Animals Production Laboratory, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archpedi.162.10.969","article-title":"Missed diagnosis of critical congenital heart disease","volume":"162","author":"R K Chang","year":"2008","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12098-019-03163-4","article-title":"Diagnosis and management of critical congenital heart diseases in the newborn","volume":"87","author":"M R Krishna","year":"2020","journal-title":"Indian J Pediatr"},{"key":"ref3","volume-title":"Critical Heart Disease in Infants and Children 2nd ed. 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